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Synthesizing Trial and Real-world Data on the Use of Biologics in Patients with Severe Asthma
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 26 Dec 2020Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025AdherenceAdrenal Cortex HormonesAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAsthmaAttentionAttitudeAwardB Cell Differentiation Factor IB Cell Differentiation Factor I GeneB cell growth factor 2B-Cell Growth Factor-IIBCGF-IIBCGF2BeliefBig DataBigDataBiologicalBiological AgentBiological ProductsBiological Response Modifier TherapyBiological TherapyBlack PopulationsBlack groupBlack individualBlack peopleBlacksBronchial AsthmaCD124Career Transition AwardCaringCessation of lifeCharacteristicsComplexCorticoidsCorticosteroidsDataData BasesDatabasesDeathDecrease disparityDisparitiesDisparityED visitEDF GeneER visitEffectivenessEmergency care visitEmergency department visitEmergency hospital visitEmergency room visitEnrollmentEo-CSFEosinophil Differentiation FactorEosinophil Differentiation Factor GeneEthnic GroupEthnic OriginEthnic PeopleEthnic PopulationEthnic individualEthnicityEthnicity PeopleEthnicity PopulationFocus GroupsGoalsHealth Insurance for Aged and Disabled, Title 18Health Insurance for Disabled Title 18HeterogeneityHispanic PopulationsHispanic groupHispanic individualHispanic peopleHispanicsHospital AdmissionHospitalizationIL-5IL-5 GeneIL4RIL4R geneIL4RAIL5IL5 geneIgA enhancing factorIgEImmunoglobulin EIndividuals from minorityIndividuals of minorityInhalationInhalingInjectableInsuranceInterleukin 5 (Colony-Stimulating Factor, Eosinophil) GeneInterleukin 5 PrecursorInterleukin 5 Precursor GeneInterleukin-5Interleukin-5 GeneInterleukinsInterventionInterviewInvestigatorsLaboratoriesLower disparityMediationMedicareMethodsMinorityMinority GroupsMinority PeopleMinority PopulationMinority individualModelingModificationMorbidityMorbidity - disease rateMotivationNegotiatingNegotiationOutcomePatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPharmaceutical EpidemiologyPharmacoepidemiologyPhasePopulationPopulation HeterogeneityPostdocPostdoctoral FellowProspective cohortProviderPuerto RicanQOLQualitative MethodsQuality of lifeRaceRacesRacial GroupRandomization trialRandomized, Controlled TrialsReportingResearchResearch AssociateResearch PersonnelResearchersRouteSourceT cell replacing factorT-Cell Replacing FactorT-Cell Replacing Factor GeneTimeTitle 18Trainingbiologicbiological therapeuticbiological treatmentbiologically based therapeuticsbiologicsbiopharmaceuticalbiotherapeutic agentbiotherapeuticsbiotherapyclinician factorsclinician-level factorscohortcomparative effectivenesscostdata basedata collected in real worlddata warehousedesigndesigningdifferences due to racedifferences in racediffers by racediffers in racedisparity eliminationdisparity reductiondiverse populationsdrug efficacydrug epidemiologyeliminate disparitieseliminating disparitiesenrollethnic minorityethnic subgroupethnicity groupevidence basehealth insurance for disabledheterogeneous populationimprovedminority patientmitigate disparitymortalitypatient oriented outcomespatients from minoritypatients of minoritypharmacoepidemiologicpharmacoepidemiologicalpharmacologicphysician factorsphysician-level factorspopulation diversitypost-docpost-doctoralpost-doctoral traineeprovider factorsprovider-level factorspublic health relevancequalitative reasoningrace based differencesrace differencesrace related differencesracialracial backgroundracial differenceracial minorityracial originracial populationracial subgroupracially differentrandomized control trialrandomized trialreal world datareduce disparityreduction in disparityresearch associatesresponsetreatment and outcometreatment effect
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Description preview
Project Summary/Abstract
African-Americans and Hispanics of Puerto-Rican origin bear a disproportionate burden of asthma morbidity
and mortality, despite decades of attention to asthma disparities. The advent of biologic therapies offers a
promising route to narrow these disparities. However, despite the well documented disparities in asthma…
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