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Syndecan-1 suppression of lung inflammation

Organization CEDARS-SINAI MEDICAL CENTERLocation LOS ANGELES, UNITED STATESPosted 25 Apr 2022Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025ARDSAcute Respiratory DistressAcute Respiratory Distress SyndromeAdult ARDSAdult RDSAdult Respiratory Distress SyndromeApoptosisApoptosis PathwayApoptoticAssayAttenuatedBioassayBiological AssayBiologyBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesCausalityCell BodyCell Communication and SignalingCell DeathCell SignalingCell surfaceCellsCessation of lifeDa Nang LungDataDeathDevelopmentDiseaseDisorderEatingEpithelial CellsEpitheliumEtiologyFailureFeedbackFood IntakeGoalsGrippeImmune responseImmunityImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIn VitroInfectionInflammationInflammatoryInflammatory ResponseInfluenzaInjuryInterventionIntracellular Communication and SignalingKnowledgeLearningLinkLungLung Alveolar EpitheliaLung InflammationLung Respiratory SystemLung damageMacrophageMarrow NeutrophilMediatingMiceMice MammalsModelingMorbidityMorbidity - disease rateMurineMusMφNecrosisNecroticNeutrophilic GranulocyteNeutrophilic LeukocyteOutcome StudyPathologicPathway interactionsPatientsPhagocytesPhagocytic CellPhagocytosisPhenotypePneumonitisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProcessProgrammed Cell DeathProteoglycanPulmonary InflammationReportingResearchResolutionRespiratory EpitheliumRisk FactorsRoleShock LungSignal TransductionSignal Transduction SystemsSignalingStiff lungStructure of respiratory epitheliumTestingTissuesViral DiseasesVirus DiseasesWild Type MouseWound Repairairway epitheliumalveolar epitheliumamebocyteattenuateattenuatesbiological signal transductioncausationdevelopmentaldisease causationflu infectionflu virus infectionhost responseimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vivoinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfluenza infectioninfluenza virus infectioninjuriesinsightlung injurylung repairlung tissue repairnecrocytosisneutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypreventpreventingprogramspulmonarypulmonary damagepulmonary injurypulmonary repairpulmonary tissue damagepulmonary tissue injuryrecruitrepairrepairedresolutionsrespiratory tract epitheliumresponsesocial rolesyndecanviral infectionvirus infectionvirus-induced diseasewet lungwildtype mousewound healingwound recoverywound resolution

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Project Summary/Abstract
Acute respiratory distress syndrome (ARDS) is initiated by a number of pulmonary and extra-pulmonary insults.

However, the lung damage becomes persistent despite treatment of the underlying etiology. Therefore, failure

of inflammation resolution is an underlying abnormality that drives the development of ARDS. Multiple…

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Syndecan-1 suppression of lung inflammation β€” CEDARS-SINAI MEDICAL CENTER | UNITED STATES | Apr 2022 | Dev Procure