grant
Synaptic mechanisms underlying reward seeking and compulsive drug use
Organization NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISMLocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAbsolute ethanolAcuteAdultAdult HumanAdverse ExperienceAdverse eventAffectAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsBedsBehavioralBrainBrain Nervous SystemCaringCocaineCocaine use disorderComplexCompulsive BehaviorCorpus StriatumCorpus striatum structureD1 receptorD2 receptorDRD2 ReceptorDevelopmentDopamineDopamine D1 ReceptorDopamine D2 ReceptorDopamine ReceptorDown-RegulationDrug usageDrugsETOHEncephalonEnvironmentEquilibriumEtOH drinkingEtOH useEthanolEthyl AlcoholFosteringGene TranscriptionGeneticGenetic TranscriptionGlobus PallidusGoalsGrain AlcoholHousingHydroxytyramineIn VitroIndividualIntakeLaboratoriesLifeLife ExperienceLocomotionMediatingMediationMedicationMethylcarbinolMiceMice MammalsModelingMurineMusNegotiatingNegotiationNerve CellsNerve UnitNeural CellNeurobiologyNeurocyteNeuronsNucleus AccumbensPharmaceutical PreparationsPhysiologyPopulationPsychological reinforcementRNA ExpressionReceptor ProteinRegulationReinforcementResearchRewardsRiskRoleSample SizeStimulantStriate BodyStriatumSubstance Use DisorderSynapsesSynapticTestingTranscriptionadulthoodalcohol behavioralcohol induced behavioralcohol ingestionalcohol intakealcohol product usealcohol related behavioralcohol responsealcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakebalancebalance functioncocaine behaviorcocaine motivated behaviorscocaine related behaviorscocaine-associated behaviorsdensitydevelopmentaldrug actiondrug misusedrug usedrug/agentearly adversityearly childhood adversityearly experienceearly life adversityethanol behaviorethanol consumptionethanol drinkingethanol induced behaviorethanol ingestionethanol intakeethanol product useethanol related behaviorethanol responseethanol useethanol use disorderexperiencein vivomalemedication misusemotivated behaviormouse modelmurine modelneurobiologicalneurobiological mechanismneuronaloptogeneticspallidumposttranscriptionalreceptorreceptor densityresponse to alcoholresponse to ethanolreward circuitrysexsocialsocial rolestriatalsubstance misusesubstance use and disordersynapsetool♂
Description preview
Project title: “Early life adversity increases striatal density of dopamine D1 receptors and promotes social alcohol drinking in mice, especially males ”
The brain’s reward circuitry remains sensitive to experience throughout early life and into adulthood, allowing individuals to adapt to their unique environments. It is thought that adverse…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click