grant
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression
NIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAcidsAcuteAgonistAminalonAminaloneAnimalsAnxietyAtivanBackBaclofenBrainBrain Nervous SystemCalciumCell Communication and SignalingCell SignalingCharacteristicsChlorophenyl GABAChronicClinicalClinical TreatmentClinical effectivenessCross-Over StudiesCrossover StudiesCycloserineDepressed moodDiseaseDisease remissionDisorderDorsumDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDrug ReceptorsDrugsEEGElectroencephalogramElectroencephalographyEncephalonEpilepsyEpileptic SeizuresEpilepticsEvoked PotentialsFDA approvedFrequenciesGABAGABA ReceptorGlutamatesHealthIndividualIntracellular Communication and SignalingKnowledgeL-GlutamateLong-Term DepressionLong-Term Synaptic DepressionLorazepamMeasuresMediatingMedicationMemantinMemantineMembraneMental DepressionMotor CortexN-Methyl-D-Aspartate ReceptorsN-Methylaspartate ReceptorsNMDA Receptor-Ionophore ComplexNMDA ReceptorsNerve Impulse TransmissionNerve TransmissionNeuronal TransmissionOutcome MeasurePCP-GABAPTSDPatientsPersonsPharmaceutical PreparationsPharmacologyPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPhysiologic pulsePlacebosPopulationPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPrefrontal CortexProtocolProtocols documentationPulseRandomizedReceptor ProteinRemissionResearchRiskRoleSafetySeizure DisorderSeizuresSeminalSham TreatmentSignal TransductionSignal Transduction SystemsSignalingSiteSymptomsSynapsesSynapticTestingTherapeuticTranscranial magnetic stimulationTranslatingVisitWorkaddictionaddictive disorderantagonismantagonistanxiousarmaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionclinical interventionclinical therapydepresseddepressed patientdepressiondesigndesigningdrug/agentepilepsiaepileptogenicgamma-Aminobutyric Acidgamma-Aminobutyric Acid Receptorsglia signalingglial signalingglutamatergicimprovedmeasurable outcomemembrane structurenerve signalingneural signalingneurobehavioralneuronal signalingneurophysiologicalneurophysiologyneurotransmissionoutcome measurementpharmacologicpost-trauma stress disorderposttrauma stress disorderpresynapticpreventpreventingprimary outcomerandomisationrandomizationrandomly assignedreceptorrepetitive transcranial magnetic stimulationresponseruminateruminationruminativesadnesssham therapysocial rolesynapsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttraumatic neurosistreatment-refractory depressiontreatment-resistant depressiontrial regimentrial treatmentγ-Aminobutyric Acid
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PROJECT SUMMARY/ABSTRACT
FDA-cleared repetitive transcranial magnetic stimulation (rTMS) protocols are known to increase cortical excit-
ability in treatment-resistant depression, but for safety and tolerability reasons, many patients receive TMS pro-
tocols designed to “quiet” overactive brain networks. Despite their common clinical and research…
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