grant
Synapse Engulfment by Oligodendrocyte Precursor Cells: A New Mechanism of Circuit Refinement in the Developing Brain
Organization COLD SPRING HARBOR LABORATORYLocation COLD SPRING HARBOR, UNITED STATESPosted 15 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20260-11 years old2-photon microscopyASDAblationAbscissionAgeAnimal BehaviorAnimalsAstrocytesAstrocytusAstrogliaAutismAutistic DisorderAxonBehavioral AssayBiologic ModelsBiologicalBiological ModelsBrainBrain DiseasesBrain DisordersBrain Nervous SystemCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChildChild YouthChildren (0-21)ComplexDataDevelopmentDiseaseDisorderDrug TherapyEarly Infantile AutismEconomic BurdenEncephalonEncephalon DiseasesExcisionExtirpationEyeEyeballFoundationsFutureGliaGlial CellsGoalsHealthHealth Care SystemsHortega cellHumanImpairmentIndividualInfantile AutismIntracranial CNS DisordersIntracranial Central Nervous System DisordersKanner's SyndromeKolliker's reticulumLifeLightLinkMediatingMiceMice MammalsMicrogliaModel SystemModern ManModernizationMolecularMonitorMurineMusNatureNerve CellsNerve UnitNeural CellNeural Stem CellNeurobiologyNeurocyteNeurodevelopmental DisorderNeurogliaNeuroglial CellsNeurologicNeurologicalNeurological Development DisorderNeuronsNeurophysiology - biologic functionNeurosciencesNon-neuronal cellNonneuronal cellOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPathway interactionsPhagocytesPhagocytic CellPhagocytosisPharmacological TreatmentPharmacotherapyPhasePhotoradiationPhysiologicPhysiologicalPlayPopulationPrevalenceProcessPropertyReceptor ProteinRemovalRoleRouteSensoryShapesSubcellular ProcessSurgical RemovalSymptomsSynapsesSynapticTechniquesTestingTherapeuticTimeTransgenic OrganismsUnited StatesViral GenesVisualVisual CortexVisual SystemWorkagesamebocyteastrocytic gliaautism spectral disorderautism spectrum disorderautistic spectrum disorderbiologicbrain cellclustered regularly interspaced short palindromic repeats screencritical perioddevelop therapydevelopmentaldrug interventiondrug treatmentexperienceexperimentexperimental researchexperimental studyexperimentsgitter cellhealth care burdenimprove symptomin vivoinsightinterdisciplinary approachintervention developmentkidslife spanlifespanmesogliamicroglial cellmicrogliocytemultidisciplinarymultidisciplinary approachmyelinationnerve cementnerve stem cellneural circuitneural circuitryneural functionneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurobiologicalneurocircuitryneurodevelopmental diseaseneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approacholigodendrocyte precursoroligodendrocyte precursor celloligodendrocyte progenitoroligodendrocyte stem celloptogeneticspathwayperivascular glial cellpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost-natal developmentpostnatalpostnatal developmentprogenitor and neural stem cellsreceptorresectionresponsesocial rolespatial and temporalspatial temporalspatiotemporalsymptom improvementsymptomatic improvementsynapsesynaptic circuitsynaptic circuitrytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapy developmenttooltranscriptomicstransgenictreatment developmenttreatment strategytwo photon excitation microscopytwo photon microscopyvisual corticalyoungster
Description preview
PROJECT SUMMARY
The establishment of synaptic connectivity during brain development involves the initial formation of an
overabundance of synapses followed by a refinement process in which some of these synapses are maintained
while others are eliminated. The precise elimination of excess synapses is driven by sensory experience during
critical…
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