grant
Suppression of ethanol dependence-induced maladaptive appetitive and consummatory behavior by the GLP-1 system
Organization DREXEL UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 1 May 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026Absolute ethanolAbstinenceAdipose tissueAffectAirAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcohol withdrawal syndromeAlcoholsAppetitive BehaviorBBB crossingBehaviorBehavior DisordersBehavioralBody WeightBody fatBrainBrain Nervous SystemBrain regionCell Communication and SignalingCell NucleusCell SignalingChronicClinicalConsummatory BehaviorConsumptionDataDevelopmentDown-RegulationDrug TargetingDrugsETOHEatingEncephalonEndocrine Gland SecretionEnsureEtOH drinkingEtOH useEthanolEthanol dependenceEthyl AlcoholExhibitsFatty TissueFemaleFoodFood IntakeFore-BrainForebrainGLP-1GLP-1 RAGLP-1 agonistGLP-1 analogGLP-1 receptorGLP-1 receptor agonistGLP-I receptorGene ExpressionGenesGlp-1Glucagon like peptide 1 agonistGlucagon like peptide-1 receptor agonistsGlucagon-like peptide-1 analogGoalsGrain AlcoholHind BrainHistoryHormonesInhalationInhalingIntakeIntermediary MetabolismIntracellular Communication and SignalingMedicationMetabolicMetabolic ProcessesMetabolismMethylcarbinolMiceMice MammalsModelingMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropeptidesNucleusNucleus AccumbensParaventricular Nucleus of ThalamusParaventricular Thalamic NucleusPeptidesPeripheralPersonsPharmaceutical PreparationsPhysiologicPhysiologicalPrefrontal CortexProsencephalonPublishingReceptor ProteinReceptor SignalingRecording of previous eventsRecoveryRegulationRelapseRewardsRhombencephalonRoleSignal TransductionSignal Transduction SystemsSignalingStressStructure of paraventricular nucleus of thalamusSystemTestingViralVisceralWithdrawalWorkadiposealcohol effectalcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol product usealcohol seekingalcohol seeking behavioralcohol usealcohol use disorderalcohol withdrawalalcoholic beverage consumptionalcoholic drink intakeantagonismantagonistbehavioral disorderbiological signal transductionblood-brain barrier crossingbloodbrain barrier crossingdesigndesigningdevelopmentaldrug/agenteat lessenergy balanceethanol addictionethanol consumptionethanol dependencyethanol dependentethanol drinkingethanol effectethanol exposedethanol exposureethanol ingestionethanol intakeethanol product useethanol seekingethanol useethanol use disorderethanol withdrawalethanol-seeking behaviorexperienceexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolfasting glucosefood Ingestionfood consumptionglucagon-like peptide 1glucagon-like peptide-1 receptorhindbrainhistoriesknock-downknockdownmRNA Expressionmalemultidisciplinaryneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypharmacologicpre-proglucagonspreproglucagonsreceptorreceptor expressionreduced eatingreduced food intakeside effectsocial rolevaporwhite adipose tissuewithdrawal from alcoholyellow adipose tissue♀♂
Description preview
PROJECT SUMMARY
People in recovery from alcohol use disorder (AUD) can experience a range of physiological and behavioral
effects during withdrawal. These effects include aberrant food consumption, and increased alcohol drinking and
seeking, which can increase stress and drive relapse. Ethanol dependence appears to dysregulate the glucagon-
like…
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