grant
Substrate-mediated collective cell migration incalvarial bone expansion and disease.
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 15 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AddressAdhesionsAffectAnimal Disease ModelsAnimal ModelAnimal Models and Related StudiesApert syndromeApicalAssayBioassayBiological AssayBirth DefectsBone GrowthBrachydanio rerioBrainBrain Nervous SystemCalvariaCausalityCell BodyCell LocomotionCell MigrationCell MovementCell-Extracellular MatrixCellsCellular MigrationCellular MotilityCephalicChimera ProteinChimeric ProteinsCold-Insoluble GlobulinsCollectionCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCongenital abnormal SynostosisCoupledCranialCraniosynostosisCuesDanio rerioDataDefectDependenceDevelopmentDifferentiation and GrowthDiseaseDisorderDysmorphologyECMEmbryoEmbryonicEncephalonEtiologyExhibitsExtracellular MatrixExtracellular Matrix ProteinsFN1Fibronectin 1FibronectinsFontanelleFusion ProteinGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneralized GrowthGeneticGenetic ModelsGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGrowthHumanImageInherited PredispositionInherited SusceptibilityLETS ProteinsLaboratoriesLarge External Transformation-Sensitive ProteinLive BirthMeasuresMediatingMesenchymasMesenchymeMiceMice MammalsModelingModern ManModificationMorphogenesisMurineMusMutant Strains MiceOperative ProceduresOperative Surgical ProceduresOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOrganOsteoblastsOutcome AssessmentPathologyPathway interactionsPatientsPatternPenetrancePhenotypePopulationPositionPositioning AttributeProteinsRegulationRoleSensorySkullStructure of fontanel of skullSubstrate InteractionSurgicalSurgical InterventionsSurgical ProcedureSurgical suturesSuturesSynostosisTestingTissue GrowthTranscript Expression AnalysesTranscript Expression AnalysisVariantVariationVertebrate AnimalsVertebratesZebra DanioZebra FishZebrafishalpha 2-Surface Binding Glycoproteinanalyze gene expressionbonecalvarialcausationcell motilityclinical relevanceclinically relevantcoronal suturecraniofacialcraniofacial disordercraniofaciescraniumdevelop therapydevelopmentaldifferential expressiondifferentially expresseddisease causationdosageexperimentexperimental researchexperimental studyexperimentsextracellulargene expression analysisgene expression assaygenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedhuman modelimagingimprovedin vivointervention developmentlive cell imagelive cell imaginglive cellular imagelive cellular imagingmigrationmodel of animalmodel of humanmorphogenetic processmouse developmentmouse geneticsmouse modelmouse mutantmurine modelmutantnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenyorgan developmentorgan growthosteoblast progenitorosteoblast stem cellosteogenic progenitorosteogenic stem cellosteoprogenitorosteoprogenitor celloverexpressoverexpressionpathwayprogenitorprogenitor cell expansionprogenitor expansionprotein expressionresponsesocial rolestem and progenitor cell expansionstem cell expansionsurgerysuture fusiontargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapy developmenttooltranscriptional differencestranscriptional profilingtreatment developmenttreatment strategyvertebrata
Description preview
Summary
Congenital defects affecting the formation of the skull roof, such as craniosynostosis or persistent fontanelles,
occur as a result of abnormal calvarial growth and differentiation. We lack a basic understanding of how calvarial
bones grow, which in turn impacts the position, patterning, and fusion of sutures, and thus etiology of these…
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