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Studying the Molecular Regulation of MGE Projection Neuron Identity by St18
Organization WINIFRED MASTERSON BURKE MED RES INSTLocation WHITE PLAINS, UNITED STATESPosted 1 Apr 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AblationAddressAdoptedAxonBasal Transcription FactorBasal transcription factor genesBiologic ModelsBiological ModelsCell BodyCell Migration AssayCell NucleusCellsChIP SequencingChIP assayChIP-seqChIPseqCollectionColoring AgentsCompetenceConnector NeuronCyclicityDefectDevelopmentDistalDorsalDoxycyclineDyesFore-BrainForebrainGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGlobus PallidusHistologyImageIn VitroIn vivo analysisIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronLabelMapsMeasuresMedialMiceMice MammalsMigration AssayModel SystemModelingMolecularMolecular ProbesMorphogenesisMorphologyMurineMusMutant Strains MiceNerve CellsNerve UnitNervous SystemNeural CellNeural Stem CellNeuritesNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNucleusPars ExternaPathway interactionsPeriodicityPopulationPositionPositioning AttributeProcessProductionProsencephalonRNA ExpressionRNA SeqRNA sequencingRNAseqRegulationRepressionRhythmicitySEQ-ANSequence AnalysesSequence AnalysisSpecific qualifier valueSpecifiedSystemTechniquesTelencephalonTestingThalamic structureThalamusTimeTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransplantationVibramycinViralalpha-6-Deoxyoxytetracyclineanalyze gene expressionchromatin immunoprecipitationchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingconditional mutantconditional mutationdevelopmentaldirected differentiationgain of functiongene expression analysisgene expression assaygene networkimagingin uteroin utero transplantationin vitro Assayin vitro Modelin vitro testingin vivoin vivo Modelin vivo evaluationin vivo testinginsightintra-uterine transplantationintrauterine transplantationloss of functionmigrationmorphogenetic processmotor controlmouse geneticsmouse mutantmutantnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornew markernovel biomarkernovel markerpallidumpathwayprenatal transplantationprogenitorprogenitor and neural stem cellsprogenitor cell differentiationprogenitor differentiationscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstem and progenitor differentiationstem cell differentiationthalamictranscription factortranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtransplant
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PROJECT SUMMARY: The medial ganglionic eminence (MGE) is a neural progenitor domain located in the ventral
telencephalon. It is well-studied for its production of cortical interneurons, a broadly distributed population of locally-pro-
jecting neurons that regulate cortical rhythmicity. The MGE also produces projection neurons that remain in the…
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