grant
Study of protein folding and misfolding by NMR spectroscopy
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AD dementiaAPF-1ATP-Dependent Proteolysis Factor 1AccelerationAddressAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimers DementiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAtmospheric PressureAβBackBiologic ModelsBiological ModelsC-terminalCausalityCollaborationsDataDegenerative Neurologic DisordersDevelopmentDiseaseDisorderDissociationDorsumEquilibriumEtiologyGillsHMG-20High Mobility Protein 20Hydrostatic PressureIsomerismKineticsL-ProlineMapsMeasuresMethodsModel SystemMolecular ConfigurationMolecular ConformationMolecular StereochemistryMonitorMsecNMR SpectrometerNMR SpectroscopyNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsParalysis AgitansParkinsonParkinson DiseasePathway interactionsPeptidesPhysiologicPhysiologicalPopulationPrimary ParkinsonismPrimary Senile Degenerative DementiaProcessProlineProteinsRelaxationSolventsStructureTechnologyTemperatureTheoretical StudiesThermodynamicThermodynamicsTimeUbiquitinWorka beta peptideaberrant protein foldingabetaabeta accumulationabeta aggregationabnormal protein foldingamyloid betaamyloid beta accumulationamyloid beta aggregationamyloid β accumulationamyloid β aggregationamyloid-b proteinaβ accumulationaβ aggregationbalancebalance functionbeta amyloid fibrilcausationcomputational studiescomputer studiesconformationconformationalconformational stateconformationallyconformationsdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldimerdisease causationexperimentexperimental researchexperimental studyexperimentsinsightisomermillisecondmonomermutantneurodegenerative illnessnovelnuclear magnetic resonance spectroscopypathologic protein foldingpathwaypolypeptidepressureprimary degenerative dementiaprotein foldingprotein misfoldingsenile dementia of the Alzheimer typesoluble amyloid precursor proteinvirtual
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Description preview
In prior years, close collaboration with Philip Anfinrud resulted in novel hardware that makes it possible possible to monitor by NMR spectroscopy the folding of a protein in a residue-specific manner upon jumping the applied hydrostatic pressure. Pressure changes of up to 2.5 kbar, requiring 1-2 ms, are feasible and compatible with the recording…
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