grant
Studies of gene fusions in rhabdomyosarcoma
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AbscissionAnimalsAssayBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer GenesCancer-Promoting GeneCancersCandidate Disease GeneCandidate GeneCas nuclease technologyCell BodyCell Communication and SignalingCell Culture SystemCell Culture TechniquesCell LineCell SignalingCellLineCellsChildhoodChimera ProteinChimeric ProteinsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsDNA Synthesis FactorDevelopmentDoseDown-RegulationDoxycyclineEmbryonic Muscle CellsEndothelial Cell Growth FactorEventExcisionExtirpationFGFFGF ReceptorsFGF-RFGF8FGF8 geneFGFBRFGFRFGFR1FGFR1 geneFKHRFLG GeneFLT2 GeneFMS-Like GeneFMS-Like Tyrosine Kinase 2 GeneFOXO1FOXO1AFOXO1A geneFeedbackFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Factor Receptor 1 GeneFibroblast Growth Factor Receptor FamilyFibroblast Growth Factor ReceptorsFibroblast Growth Regulatory FactorForkhead Box O1AForkhead in RhabdomyosarcomaFusion ProteinGene FusionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGenetic studyGoalsHBGF-8HUP2HumanIn VitroIntracellular Communication and SignalingLaboratory miceLigandsMEKsMYCNMYCN geneMaintenanceMalignant NeoplasmsMalignant TumorMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorModelingModern ManMolecularMonitorMyoblastsNMYCNMYC GeneNeoplasm MetastasisNerve CellsNerve UnitNeural CellNeurocyteNeuronsOncogene ProductsOncogene ProteinsOncogenesOncogenesisOncogenicOncoproteinsPAX3PAX3 genePaired Box Gene 3Paired Domain Gene HuP2PathogenicityPathway interactionsPatientsPharmacological StudyPharmacology StudyPhenotypePhosphotyrosinePoint MutationPopulationPrecursor Muscle CellsPrimary NeoplasmPrimary TumorRNA ExpressionReceptor InhibitionRecurrenceRecurrentRecurrent NeoplasmRecurrent tumorRelapseRemovalResidualResidual stateRhabdomyosarcomaRoleSecondary NeoplasmSecondary TumorSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesSurgical RemovalSystemTestingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransforming GenesTumor CellTumor-DerivedTumorigenicityTyrosine-O-phosphateUpregulationVibramycinWS1alpha-6-Deoxyoxytetracyclinebiological signal transductioncDNA Expressioncancer metastasiscancer progressioncell culturecell culturescultured cell linedevelopmentalexperimentexperimental researchexperimental studyexperimentsgenetic analysisgenome scalegenome-widegenomewidein vivoinhibitorknock-downknockdownmalignancyneoplasm progressionneoplasm recurrenceneoplasm/cancerneoplastic cellneoplastic progressionneuronalnovelpathwaypediatricreceptor expressionresectionresistance mechanismresistant mechanismscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesoft tissuetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscription factortumortumor cell metastasistumor progressiontumorigenesistumorigenic
Description preview
In our previous studies, we elucidated the mechanisms related to fibroblast growth factor (FGF) signaling in RMS tumors. Within this pathway, the genes for both FGF8 (an FGF ligand) and FGFR4 (an FGF receptor) are downstream transcriptional targets of PAX3::FOXO1 (P3F). We previously used a myoblast model of fusion-positive rhabdomyosarcoma…
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