grant
Structures and Pharmacology of Cation-Chloride Cotransporters
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 20 Sept 2021Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2026AbscissionAccelerationAffectAmino Acid SequenceAnionsAnti-Hypertensive AgentsAnti-Hypertensive DrugsAnti-HypertensivesAssayBenzothiadiazine DiureticsBindingBioassayBiochemicalBiochemical ReactionBiological AgentBiological AssayBiological ProductsBlood PressureBlood VolumeBrainBrain DiseasesBrain DisordersBrain Nervous SystemBumetanideBumexCationsCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell VolumesCell membraneCellular FunctionCellular PhysiologyCellular ProcessChemicalsChloridesCo-TransportersComplexCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmic MembraneDNA mutationDephosphorylationDevelopmentDiseaseDisorderDissectionDiureticsDropsyDrugsE3 LigaseE3 Ubiquitin LigaseEdemaElectrolyte BalanceElectron CryomicroscopyEncephalonEncephalon DiseasesEnzymatic ReactionEpilepsyEpileptic SeizuresEpilepticsEpitheliumEquilibriumExcisionExhibitsExtirpationFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFamilyFiltrationFiltration FractionationFluorescenceFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsFoundationsFrusemidFurosemideFursemideGAP ProteinsGDP Dissociation FactorGDP Dissociation StimulatorsGDP Exchange FactorsGDP-GTP Exchange ProteinGDP-GTP Reversing FactorsGTP GDP exchange factorGTPase-Activating ProteinsGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGuanineGuanine Nucleotide Exchange FactorsGuanine Nucleotide Exchange ProteinGuanine Nucleotide Releasing FactorsGuanyl-Nucleotide Exchange FactorGuanyl-Nucleotide Releasing FactorHigh Throughput AssayHumanHydropsHypertensionHypotensive AgentHypotensive DrugsHypotensivesIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersIon CotransportIon TransportIonsIsoformsKidneyKidney Urinary SystemKinasesKnowledgeLeadLearningLigandsLightMediatingMedicationMembraneModern ManMolecularMolecular Dynamics SimulationMolecular InteractionMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMovementMutagenesisMutagenesis Molecular BiologyMutationN-terminalNH2-terminalNatureNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeural TransmissionNeurocyteNeuronsNeurotransmittersOutcomePb elementPharmaceutical PreparationsPharmacologyPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPhosphorylationPhosphorylation InhibitionPhosphotransferase GenePhosphotransferasesPhotoradiationPlasma MembranePlayPrimary Protein StructurePropertyProtein DephosphorylationProtein IsoformsProtein PhosphorylationProteinsProteomicsRNA SplicingRadioactiveRegulationRemovalResolutionRoleSaltsSeizure DisorderSeizuresSignal TransductionSignal Transduction SystemsSignalingSiteSmall G-ProteinsSmall GTPasesSodium ChlorideSpecificitySplicingStructureStructure-Activity RelationshipSubcellular ProcessSurgical RemovalSymportSynaptic TransmissionSyndromeTM DomainTestingTherapeuticThiazide DiureticsTracerTransmembrane DomainTransmembrane RegionTransphosphorylasesUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UrineVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderVesicleVisualizationabsorptionantagonismantagonistanti-hypertensionbalancebalance functionbiological signal transductionbiologicsbiopharmaceuticalbiotherapeutic agentbody movementchemical bondchemical structure functioncryo-EMcryoEMcryogenic electron microscopydevelopmentaldrug developmentdrug induced hearing impairmentdrug induced hearing lossdrug/agentepilepsiaepileptogenicexchange factorfamilial hyperkalemic hypertensiongenome mutationguanosinetriphosphatase activating proteinheavy metal Pbheavy metal leadhigh blood pressurehigh throughput screeninghyperpiesiahyperpiesishypertension treatmenthypertensive diseasehypertensive disorderimprovedinnovateinnovationinnovativeinterdisciplinary approachmembermembrane structuremolecular dynamicsmultidisciplinary approachneuronalneuronal excitabilitynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachototoxicototoxicitypermanent hearing losspharmacologicplasmalemmapressureprotein sequencerenalresectionresolutionssaltside effectsocial rolestructure function relationshipsymportersynapse inhibitionsynaptic inhibitiontherapeutic targettraffickingubiquitin-protein ligase
Description preview
Project Summary
Human cation-chloride cotransporters (CCCs) consist of three Na+-dependent Na+-(K+)-Cl- (NCC and NKCC1-
2) and four Na+-independent K+-Cl− (KCC1-4) transporters. CCCs drive the symport of Cl- with Na+ and/or K+
across membrane and play pivotal roles in cell volume regulation, trans-epithelia ion movement, and regulation
of…
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