grant
Structures and Activities of Prions and Prion Proteins
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Amino Acid SequenceAmyloid FibrilsArtifactsBehaviorBeta SheetBindingBody TissuesBovine Spongiform EncephalitisBovine Spongiform EncephalopathyBrainBrain Nervous SystemC-terminalCJDCell BodyCell FunctionCell PhysiologyCell ProcessCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelCentrifugationCentrifugation FractionationCharacteristicsChronic Wasting DiseaseClinicalCreutzfeldt-Jacob DiseaseCreutzfeldt-Jakob DiseaseCreutzfeldt-Jakob SyndromeCryo-electron MicroscopyCryoelectron MicroscopyDeerDegenerative Neurologic DisordersDetergentsDevelopmentDiseaseDisorderDisparateElectron CryomicroscopyElectron MicroscopyElementsEncephalonExclusionFarm AnimalGoalsHCG beta coreHealthHumanJakob-Creutzfeldt DiseaseLesionLivestockLobeMad Cow DiseaseMicellesModelingModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular Sieve ChromatographyMolecular StereochemistryMontanaMorphologic artifactsNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsPRNPPathogenesisPathologicPatientsPhysiologicPhysiologicalPrPPrP ProteinsPrP genePrPScPrPSc ProteinsPreparationPrimary Protein StructurePrion DiseasesPrion Protein DiseasesPrion ProteinsPrion protein genePrion-Induced DisorderPrionsProcessPublishingReportingResolutionRodentRodentiaRodents MammalsScrapieScrapie AgentScrapie PrPSize Exclusion ChromatographyStructureSubacute Spongiform EncephalopathySubcellular ProcessSurfaceTailTemperatureTestingTherapeuticTimeTissuesTransmissible DementiasTransmissible Spongiform EncephalopathiesTransmissionUGF-HCGUGP peptideVaccinesWorkbeta pleated sheetcervidcommunicable disease transmissionconformationconformationalconformational stateconformationallyconformationscore fragmentcryo-EMcryoEMcryogenic electron microscopydegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldimerdisease transmissiondisease-associated PrPexperimentexperimental researchexperimental studyexperimentshuman chorionic gonadotropin beta-subunit core fragmentin vivoinfectious disease transmissionlight scatteringlight scattering measurementlobesmolecular dynamicsnephelometryneurodegenerative illnessneuropathologicneuropathologicalneuropathologyparticlepreparationspreservationprion disorderprotein sequenceresolutionssedimentation velocitysimulationspongiform degenerationspongiform encephalopathytransmission processurinary gonadotropin fragmenturinary gonadotropin peptideβ-Sheetβ-pleated sheet
Description preview
CWD prion structure: In a given type of mammalian host, prion strains are distinguished by differences in clinical presentation, neuropathological lesions, survival time, and characteristics of the infecting prion protein (PrP) assemblies. We previously determined the near-atomic structures of 3 rodent prion strains. This fiscal year we determined…
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