grant
Structure-guiding tools to study the role of choline in the development of congenital hydrocephalus
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20252-AminoethanolAddressAminoethanolsAntibodiesAssayBBB disruptionBindingBioassayBiologicalBiological AssayBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood VesselsBlood brain barrier dysfunctionBlood-Brain BarrierBrainBrain Nervous SystemBrain VentricleCNS DiseasesCNS Nervous SystemCNS disorderCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell Culture TechniquesCell DifferentiationCell Differentiation processCell membraneCellsCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersCerebral VentriclesCerebrospinal FluidCholineClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyColamineCollaborationsCommunitiesComplexCongenital HydrocephalusCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmic MembraneDNA mutationDataDevelopmentDietDiseaseDisorderDrug DeliveryDrug Delivery SystemsElectron CryomicroscopyEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthanolaminesFerroprotoporphyrinFutureGeneralized GrowthGenerationsGeneticGenetic ChangeGenetic defectGenetic mutationGenotypeGoalsGrowthHemato-Encephalic BarrierHemeHumanHydrocephalusHydrocephalyImpairmentIn VitroIntermediary MetabolismIonsKO miceKnock-inKnock-outKnock-out MiceKnockoutKnockout MiceLinkMapsMediatingMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManModificationMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonoethanolamineMovementMurineMusMutateMutationNatureNerve Impulse TransmissionNerve TransmissionNeural Stem CellNeuraxisNeuronal TransmissionNull MouseNutrientPathogenesisPatientsPhenotypePlasma MembranePlayProliferatingPropertyProtein TraffickingProteinsProtohemePublishingRadioactiveRecombinantsReporterResearchResolutionRoleSeriesStructural ModelsStructureStructure-Activity RelationshipSystemTestingTherapeuticTissue GrowthTracerVascularizationVentricularaxon signalingaxon-glial signalingaxonal signalingbiologicblood-brain barrier disruptionbloodbrain barrierbloodbrain barrier disruptionbody movementbrain endothelial cellbrain microvascular endothelial cellbrain vascular endothelial cellcell culturecell culturescellular differentiationcerebral endothelial cellcerebral microvascular endothelial cellcerebral spinal fluidcerebral vascular endothelial cellchemical structure functioncholine transporterconditional knock-outconditional knockoutconditional mutantconditional mutationconformationconformationalconformational stateconformationallyconformationscross reactivitycryo-EMcryoEMcryogenic electron microscopydevelopmentaldietsepigeneticallyexperimentexperimental researchexperimental studyexperimentsferrohemegenome mutationglia signalingglial signalinghigh-affinity choline transporterhydrocephalicin vivoinnovateinnovationinnovativeinsightknockinmembrane synthesismouse modelmurine modelnerve signalingnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural signalingneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal signalingneuronal stem cellsneuroprogenitorneurotransmissionnovelontogenyplasmalemmaprogenitor and neural stem cellsprotein transportresolutionssocial rolespinal fluidstructural biologystructure function relationshiptooltraffickingvascular
Description preview
PROJECT SUMMARY
The blood-brain barrier (BBB) is a term used to describe the unique properties of the blood vessels that
vascularize the central nervous system (CNS) and restrict the movement of nutrients, ions and cells between
the blood and the brain. BBB dysfunction contributes to various CNS diseases and greatly impedes drug delivery.
Despite…
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