grant
Structure-guided design of durable pan-lyssavirus vaccines and anti-viral antibody therapies
Organization MONTANA STATE UNIVERSITY - BOZEMANLocation BOZEMAN, UNITED STATESPosted 15 Apr 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY20260-11 years oldAddressAffectAffinityAmino AcidsAnti-viral AgentsAnti-viral TherapyAntibodiesAntibody Binding SitesAntibody ResponseAntibody TherapyApplications GrantsAssayBindingBinding ProteinsBinding SitesBioassayBiologicalBiological AssayBlocking AntibodiesBlood SerumCell BodyCell surfaceCellsChildChild YouthChildren (0-21)Clinical Treatment MoabCombining SiteComplexConduct Clinical TrialsCryo-electron MicroscopyCryoelectron MicroscopyDataData BasesDatabasesDevelopmentEducational workshopElectron CryomicroscopyElectron MicroscopeElectron MicroscopyEquipmentFeedbackFoundationsFutureGlycansGlycohydrolasesGlycoproteinsGlycosidasesGlycoside HydrolasesGoalsGrantGrant ProposalsHumanHuman ResourcesImageIndividualInfectionInterferometryInvestigatorsIsoformsKnowledgeLaboratoriesLegal patentLifeLigand Binding ProteinLigand Binding Protein GeneLight MicroscopeLinkLogisticsLyssavirusManpowerManuscriptsMapsMarketingMentorsModern ManModernizationMolecularMolecular InteractionMonoclonal AntibodiesNicotinic Acetylcholine ReceptorsNicotinic ReceptorsOutcomeParatopesPatentsPathogenesisPersonsPolysaccharidesProcessProtein BindingProtein IsoformsProteinsPublishingRabiesRabies Human Diploid Cell VaccineRabies VaccinesRabies lyssavirusRabies mappingRabies trans synaptic tracingRabies virusRabies virus mediated mappingReactive SiteReceptor ProteinResearchResearch PersonnelResearch ResourcesResearchersResolutionResourcesSerumSiteStructureSurfaceTechnical ExpertiseTechniquesTestingTherapeuticTherapeutic antibodiesTrainingTranslational ResearchTranslational ScienceVaccinatedVaccinationVaccine DesignVaccinesViralViral AntibodiesVirusWorkWorkshopWritingaminoacidanti-viral antibodyanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsantibody based therapiesantibody combining siteantibody engineeringantibody treatmentantibody-based therapeuticsantibody-based treatmentbiologicbound proteincostcrosslinkcryo-EMcryoEMcryogenic electron microscopydata basedesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldruggable targethigh definitionhigh-resolutionimagingimprovedindustrial partnershipindustry partnerindustry partnershipintervention designkidslyssamAbsmonoclonal Absneuralneutralizing antibodypersonnelpolyclonal antibodypreventpreventingprotein protein interactionprotein structureprotein structuresproteins structurerabies based mappingrabies based retrograde mappingrabies circuit tracingrabies mediated retrograde monosynaptic tracingrabies retrograde tracingrabies tracerrabies tracingrabies vaccinationrabies viral tracingrabies virus G proteinrabies virus glycoproteinrabies virus glycoprotein Grabies virus mediated circuit mappingrabies virus monosynaptic circuit tracingrabies virus monosynaptic tracingrabies virus neurotracerrabies virus retrograde tracingrabies virus tracingrabies virus vaccinationrational designreceptorreceptor bindingreceptor boundresolutionssmall moleculetechnical skillstherapy designtracing with rabiestranslation researchtranslational investigationtreatment designuptakevaccine antibodiesvaccine developmentvaccine induced antibodiesvaccine-induced antibodiesviral infectious disease treatmentviral testingvirologyvirus testingyoungster
Description preview
Project Summary
Untreated rabies infections are nearly 100% lethal and kill over 50,000 people every year,
disproportionately affecting children. While lifesaving, current rabies vaccines and post-exposure therapies can
be prohibitively expensive and do not elicit long-lasting protection, with some individuals needing revaccination
as frequently…
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