grant

Structure and regulation of lipid metabolism and transport

Organization STATE UNIVERSITY NEW YORK STONY BROOKLocation STONY BROOK, UNITED STATESPosted 1 Aug 2018Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20251,2-diacylglycerol3-sn-Phosphatidate phosphohydrolaseAnabolismAssayBindingBioassayBiochemicalBiologicalBiological AssayCancersCardiac DiseasesCardiac DisordersCardiovascular DiseasesCarrier ProteinsCell Growth in NumberCell LocomotionCell MigrationCell MovementCell MultiplicationCell ProliferationCell membraneCellular MigrationCellular MotilityCellular ProliferationCholine GlycerophospholipidsCholine PhosphoglyceridesComplexCytoplasmic MembraneDephosphorylationDeuteriumDiabetes MellitusDiacylglycerolsDiglyceridesEnzyme GeneEnzymesFatsFatty AcidsFatty acid glycerol estersFoundationsFundingGoalsH elementH2 isotopeHeart DiseasesHydrogenHydrolysisInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntermediary MetabolismIntracellular Second MessengerIonsKnowledgeLecithinLecithinase DLinkLipid BiochemistryLipid TraffickingLipidsLipoproteinsMalignant NeoplasmsMalignant TumorMammalian CellMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMembraneMetabolic ProcessesMetabolismMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular Mechanisms of ActionMolecular StereochemistryNuclear EnvelopeNuclear MembraneObesityPhosphatidate PhosphatasePhosphatidate PhosphohydrolasePhosphatidesPhosphatidic AcidPhosphatidic Acid PhosphatasePhosphatidic Acid PhosphohydrolasePhosphatidyl InositolPhosphatidylcholine PhosphohydrolasePhosphatidylcholinesPhosphatidylinositolsPhosphoinositidesPhospholipase DPhospholipidsPhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhysiologicPhysiologicalPlasma MembranePlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProtein DephosphorylationProtein ModificationProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein phosphataseProteinsPtdInsReceptor ProteinRegulationRoleSecond Messenger SystemsSecond MessengersSiteStimulusStructureSubstrate SpecificityTransport Protein GeneTransport ProteinsTransporter ProteinTriacylglycerolTriglyceridesVision DisordersVisual DisorderWorkadipositybiologicbiosynthesiscardiovascular disordercell motilityconformationconformationalconformational stateconformationallyconformationscorpulencediabetesdiacylglyceroldiglycerideextracellularfat metabolismheart disorderhuman diseaseimprovedinsightinsulin sensitivityinterestlipid exchange proteinlipid metabolismlipid transfer proteinlipid transportlipinlipinelipophosphodiesterase IImalignancymembrane structureneoplasm/cancerpharmacologicphosphatidylcholine phosphatidohydrolaseplasmalemmaprotein functionreceptorresponsesignal transduction second messengerssocial roletherapeutic targettrafficking
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PROJECT SUMMARY: We are interested in understanding how lipid-metabolizing enzymes and lipid transport
proteins function and are regulated at the molecular and structural level. Previously, we focused on two enzymes
in phosphatidic acid (PA) metabolism: lipin and phospholipase D (PLD). Lipins are PA phosphatases that
dephosphorylate PA to generate…

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Structure and regulation of lipid metabolism and transport — STATE UNIVERSITY NEW YORK STONY BROOK | UNITED STATES | Aug | Dev Procure