grant
Structure and Functional Consequences of Serine vs. Threonine Mucin-Type O-linked Glycosylation
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025Ab responseAnimalsAntibodiesAntibody FormationAntibody ProductionAntigensBladderBladder DiseasesBladder DisorderBladder NeoplasmBladder TumorsBladder Urinary SystemCA-15-3 AntigenCell Growth in NumberCell MultiplicationCell ProliferationCellular ProliferationCollaborationsDF3 AntigenDataEpisialinEpithelial Membrane AntigenEpitheliumGlycansGlycopeptidesGlycosylated MUC-1GoalsImmune mediated therapyImmune systemImmunizationImmunizeImmunologically Directed TherapyImmunotherapeutic agentImmunotherapyInterstitial CystitisL-SerineL-ThreonineLinkMUC-1 AntigenMUC1 antigenMalignant CellMalignant Pancreatic NeoplasmMalignant neoplasm of pancreasMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMetabolic GlycosylationModernizationModificationMolecular ConfigurationMolecular ConformationMolecular StereochemistryMucin Peptide MUC-1Mucin/PeptideMucinsMucus GlycoproteinMutateN-Acetylneuraminic AcidsPancreas CancerPancreatic CancerPatientsPeptidesPolymorphic Epithelial MucinPolysaccharidesPositionPositioning AttributeProliferatingPropertyResolutionSerineSialic AcidsSiteStructureSubstrate SpecificitySynthetic ImmunogensThreonineTransferaseTransferase GeneTrisaccharidesUrinary Bladder NeoplasmUrinary Bladder TumorUrineVaccine DesignWorkanaloganti-proliferative agentsantibody biosynthesisantiproliferative agentsbladder pain syndromecancer cellconformationconformationalconformational stateconformationallyconformationsdesigndesigningfeature detectionfeature recognitionglycoproteomicsglycosylationimmune drugsimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunoglobulin biosynthesisimmunologic therapeuticsimmunotherapeuticsimmunotherapy agentnano-molarnanomolaroverexpressoverexpressionpainful bladder syndromepancreatic cancer cellspancreatic malignancypancreatic tumor cellspeptide aminoacid sequencepeptide sequenceprogramsprotein aminoacid sequenceresolutionsresponsesialylationsugarsynthetic DNAsynthetic constructtooltumorurinary bladderurinary bladder disorder
Description preview
In previous studies (which have been discontinued for this cycle) we have studied the properties of a unique glycopeptide called antiproliferative factor (APF), that is found in the urine of patients with a bladder disease called interstitial cystitis/painful bladder syndrome (IC/PBS). APF is a potent antiproliferative agent, inhibiting normal…
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