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Structure and function of the monotopic phosphoglycosyl transferase superfamily: Initiators of biosynthesis of complex bacterial glycoconjugates

Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 1 Feb 2019Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025Active SitesAnabolismAnti-Bacterial AgentsAntigenic DeterminantsAssayBacteriaBase SequenceBindingBinding DeterminantsBioassayBiochemicalBiochemistryBioinformaticsBiologicalBiological AssayBiological ChemistryBiologyBiopolymersBisphosphonatesCell FunctionCell PhysiologyCell ProcessCell membraneCellular FunctionCellular PhysiologyCellular ProcessChemicalsClassificationCommunitiesComplexCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmCytoplasmic MembraneDedicationsDehydrogenasesDetergentsDevelopmentDiphosphatesE coliE. coliEC 2.4Electron CryomicroscopyElectrostaticsEnzyme GeneEnzymesEpitopesEscherichia coliFaceFamily memberFingerprintGenesGenomeGlycansGlycoconjugatesGlycoside TransferasesGoalsHigh Throughput AssayHumanIn VitroKnowledgeLibrariesLigandsMembraneModern ManMolecular InteractionNeighborhoodsNucleotide SequenceNucleotidesO elementO2 elementOperonOxidoreductaseOxidoreductase GeneOxygenPathogenesisPathway interactionsPhenotypePhosphatesPlasma MembranePlayPolysaccharidesProteinsPyrophosphatesReductasesRegulationResolutionRoentgen RaysRoleS PeriodS phaseSEQ-ANSequence AlignmentSequence AnalysesSequence AnalysisSingle Crystal DiffractionSolidSpecificityStructureSubcellular ProcessSubstrate SpecificitySynthesis PeriodSynthesis PhaseSystematicsTestingThymidinThymidineTransferaseTransferase GeneUDP SugarsUrdUridineUridine Diphosphate SugarsVirulenceWorkX Ray CrystallographiesX-RadiationX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray RadiationX-Ray/Neutron CrystallographyX-rayXrayXray Crystallographyanaloganti-bacterialbacteria pathogenbacterial pathogenbiologicbiosynthesisbiphosphonatebisphosphonatecarbenecell envelopecomputational studiescomputer studiescryo-EMcryoEMcryogenic electron microscopydesigndesigningdevelopmentaldiphosphonateempowermentfacesfacialgene functionglycosyltransferasehigh throughput screeningin vivoinhibitorinorganic phosphateinsightlipid based nanoparticlelipid nanoparticlemacromoleculemembermembrane structuremetermethylenenucleic acid sequencenucleoside analognucleoside diphosphateparallel computationparallel computerparallel computingpathogenic bacteriapathwayplasmalemmapreventpreventingprotein foldingprotein protein interactionresolutionssequencing alignmentsmall moleculesocial rolestructural biologysugarsugar nucleotidesymbiontsynergismtherapeutic targettool

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Description preview

Complex glycoconjugates play a pivotal role in bacterial survival, colonization, and virulence, and
contribute to the interactions between symbiotic and pathogenic bacteria and their human hosts. Assembly
of these macromolecules is initiated on the cytoplasmic face of cell membranes, catalyzed by polyprenol
phosphate (PrenP) phosphoglycosyl…

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