grant
Structural systems biology of microenvironmental oxidative stress and synthetic biology intervention
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Aug 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DActive OxygenAcute Radiation SyndromeAgingAssayBacteriaBindingBioassayBiochemical PathwayBiological AssayCell BodyCellsCellular StressCellular Stress ResponseConserved SequenceData AnalysesData AnalysisDiagnosisDiseaseDisorderDysfunctionE coliE. coliEcological impactEngineeringEnvironmental ImpactEscherichia coliFoundationsFunctional disorderFutureGAPDGlyceraldehyde-3-Phosphate DehydrogenasesGlyceraldehydephosphate DehydrogenaseHumanIn VitroIntermediary MetabolismInterventionLeadMachine LearningMetabolicMetabolic NetworksMetabolic ProcessesMetabolic dysfunctionMetabolismMitochondrial ProteinsModelingModern ManMolecularMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMolecular and Cellular BiologyOrganismOutcomeOuter Mitochondrial MembraneOxidation-ReductionOxidative StressOxygen RadicalsPb elementPhenotypePhosphoglyceraldehyde DehydrogenasePhysiopathologyPro-OxidantsPropertyProtein EngineeringProteinsProteomeProteomicsRadiation ToxicityRadiotoxicityReactive Oxygen SpeciesRecombinantsRedoxResearchResistanceResolutionSiteStressStructure-Activity RelationshipSystems BiologyTechnologyTestingTheoretic ModelsTheoretical modelTherapeuticTriosephosphate DehydrogenaseVariantVariationWorkbiological systemscell stresschemical structure functiondata interpretationdesigndesigningdiagnostic developmentenzyme activitygenetic protein engineeringgenome scalegenome-widegenomewideheavy metal Pbheavy metal leadhuman diseaseinterestliving systemmachine based learningmetabolism measurementmetabolomicsmetabonomicsmitochondrial dysfunctionmitochondrial membranemolecular modelingoxidationoxidation reduction reactionoxidative damageoxidative injurypathophysiologyprotein designprotein functionprotein structureprotein structure functionprotein structuresproteins structureradiation poisoningrational designreconstructionresistantresolutionssimulationstructure function relationshipsynthetic biologytherapeutic agent developmenttherapeutic developmentthree dimensional
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ABSTRACT
I seek to characterize proteomic and fundamental molecular properties of bacteria and human cells under
oxidative stress as a means to understand mechanistic underpinnings of sensitivity phenotypes.
1) Oxidative stress broadly impacts protein function, but it is very challenging to experimentally determine
which protein malfunctions lead…
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