grant
Structural regulation of megalin recycling in the proximal tubule
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 15 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AdoptedAdvisory CommitteesAffinityAlbuminsAlkalinizationAmino AcidsApicalAssayAwardBackBasic ResearchBasic ScienceBindingBinding ProteinsBinding SitesBioassayBiological AssayBiological MarkersBowman's spaceCRISPRCRISPR/Cas systemCURLCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell SignalingCell membraneCell surfaceCellsChaperoneChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinical TreatmentClustered Regularly Interspaced Short Palindromic RepeatsCombining SiteCompartment of the Uncoupling Receptors and LigandsCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmic MembraneDNA mutationDependenceDidelphidaeDiseaseDisorderDissociationDorsumEGATAEGTAEarly EndosomeEgtazic AcidElectron CryomicroscopyEndocytosisEndosomesEpithelial CellsEventFiltrationFiltration FractionationFutureGEDTAGP330 AntigenGenetic ChangeGenetic defectGenetic mutationGlycoprotein 330GoalsHeart VascularHeyman's Nephritis Antigen GP330Heymann Nephritis Antigen GP330ImmunofluorescenceImmunofluorescence ImmunologicInstitutionIntracellular Communication and SignalingInvestigatorsIonsKidney TubulesLDL-Receptor Related Protein 2LRP-2LRP-2 ReceptorLaboratory ResearchLife CycleLife Cycle StagesLigand BindingLigand Binding ProteinLigand Binding Protein GeneLigandsLow-Density Lipoprotein Receptor-Related Protein-2Mass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMegalinMentorsMolecularMolecular ChaperonesMolecular InteractionMolecular WeightMutateMutationNephritis Antigen GP 330OpossumsPhysiciansPlasma MembraneProcessProtein BindingProteinsProteinuriaProximal Kidney TubulesPublishingR-Series Research ProjectsR01 MechanismR01 ProgramReactive SiteReceptor ProteinReceptosomesRecyclingRegulationRenal CellRenal Glycoprotein GP330Renal tubule structureResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersScientistSignal TransductionSignal Transduction SystemsSignalingSortingStructureSurfaceSurface Plasmon ResonanceTask ForcesTestingTrainingTranslatingTubularTubular formationUniversitiesUrinary SpaceUrineVariantVariationWorkabsorptionadvisory teamaminoacidapical membranebio-markersbiologic markerbiological signal transductionbiomarkerbound proteincareercareer developmentchelationchronic kidney diseasecirculatory systemclinical interventionclinical therapycryo-EMcryoEMcryogenic electron microscopydesigndesigningexperienceexperimentexperimental researchexperimental studyexperimentsgenome mutationglomerular filtrationgp 330kidney celllate endosomelife coursemutantparticleplasmalemmaprotein complexprotein structureprotein structuresproteins structurereceptorreceptor recyclingreconstructionrenal proximal tubulerenal tubulestoichiometrystructural biologytraffickingtrial regimentrial treatmenturinary
Description preview
Abstract
This K08 Career Development Proposal details the candidate’s research on the structural regulation of megalin
recycling in the kidney proximal tubule (PT) that will be conducted during a 5-year mentored award period.
With the guidance of his co-mentors at Columbia University, Dr. Shapiro and Dr. Barasch, along with oversight
from an…
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