grant
Structural Investigation of the Central Components of the CD4+ T Cell Immunological Synapse
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AddressAdhesionsAdhesivesAffectAffinityAllosteric RegulationAntigen-Presenting CellsBindingCD3CD3 AntigensCD3 ComplexCD3 moleculeCD4 AntigensCD4 CellsCD4 MoleculeCD4 Positive T LymphocytesCD4 ProteinCD4 ReceptorsCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8BCD8B1CD8B1 geneCell BodyCell Communication and SignalingCell SignalingCellsComplexCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyDNA mutationDataDetergentsDevelopmentDiseaseDisorderDysfunctionElectron CryomicroscopyEndosomesEngineeringEnvironmentFunctional disorderFutureGenetic ChangeGenetic defectGenetic mutationGoalsHumanImmune systemImmunomodulationIndividualIntracellular Communication and SignalingInvestigationKinasesLYT3LengthLigandsLocationLymphocyte-Specific Protein-Tyrosine KinaseLymphocyte-Specific p56LCK Tyrosine Protein KinaseMHC ReceptorMHC binding peptideMajor Histocompatibility Complex ReceptorMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodsModelingModern ManMolecularMolecular InteractionMutationOKT3 antigenOKT4 antigenPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPhosphotransferase GenePhosphotransferasesPhysiopathologyPositionPositioning AttributeProtein Tyrosine Kinase p56(lck)ProteinsProto-Oncogene Protein c-lckProto-Oncogene Protein lckProto-Oncogene Tyrosine-Protein Kinase LCKPublishingReceptor ActivationReceptor ProteinReceptor SignalingReceptosomesReportingResolutionRoleSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling MoleculeSignaling Pathway GeneSignaling ProteinSortingStructural ModelsStructureSurface CD4 ReceptorsSurface ProteinsT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell ActivationT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell Specific Protein Tyrosine KinaseT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyT3 AntigensT3 ComplexT3 moleculeT4 CellsT4 LymphocytesT4 moleculeTailTheoretic ModelsTheoretical modelTransphosphorylasesVariantVariationVirus-like particleVisualizationaccessory cellactivate T cellsadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapybiological signal transductioncomputer based predictioncryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydevelopmentalelectron cryo-tomographyengineered T cellsgenetically engineered T-cellsgenome mutationhelper T lymphocyte markerhuman diseaseimmune modulationimmune regulationimmunologic reactivity controlimmunological synapseimmunomodulatoryimmunoregulationimmunoregulatoryinsightlck Kinasemembermembrane structuremutantnovelp56 lckpMHCparticlepathophysiologypredictive modelingprotein complexreceptorreceptor bindingreceptor boundreceptor functionrecruitresolutionsself assemblysocial roletherapeutic T-cell platformthymus derived lymphocytetransgenic T- cellsvirus-like nanoparticlesviruslike particle
Description preview
Project Summary
After nearly four decades since the first crystal structure of a human MHC was published, it is still
unclear how exactly T cells engage and become activated by peptide-MHC (pMHC) presented on host
cells. T cells are a cornerstone of the immune system, and the interface between T cells and host cells
consists of an ensemble of…
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