grant
Structural dynamics and energy landscapes of G protein signaling
Organization CALIFORNIA STATE UNIVERSITY NORTHRIDGELocation NORTHRIDGE, UNITED STATESPosted 1 Jun 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMP3,5 cyclic AMP synthetaseADRB2ADRB2 geneADRB2RADRBRAVPR2AVPR2 geneAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)Adenyl CyclaseAdenylate CyclaseAdenylyl CyclaseAdrenergic AgentsAdrenergic DrugsAdrenergicsAffectAgonistAlanineAreaArrestinsAssayB2ARBeta-2 Adrenergic Receptor GeneBeta-2 Adrenoceptor GeneBindingBinding ProteinsBioassayBiochemicalBiological AssayBiophysicsCAR orphan nuclear receptorCB1CB1 ReceptorCB1RCNR1 geneCannabinoid Receptor CB1CardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCatecholamine Receptor GeneCell BodyCell Communication and SignalingCell SignalingCellsComplexComputing MethodologiesCoupledCouplesCouplingCryo-electron MicroscopyCryoelectron MicroscopyCyclic AMPCytoplasmD1 receptorD2 receptorDI1DRD2 ReceptorDiseaseDisorderDissociationDopamine D1 ReceptorDopamine D2 ReceptorElectron CryomicroscopyEndocrine Gland SecretionExhibitsFRETFluorescence Resonance Energy TransferFutureFörster Resonance Energy TransferG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG alpha q ProteinG-Protein Regulating FactorsG-Protein Signaling RegulatorsG-Protein-Coupled ReceptorsG-ProteinsGDP Dissociation FactorGDP Dissociation StimulatorsGDP Exchange FactorsGDP-GTP Exchange ProteinGDP-GTP Reversing FactorsGPCRGTPGTP BindingGTP GDP exchange factorGTP boundGTP-Binding Protein Regulating FactorsGTP-Binding Protein RegulatorsGTP-Binding ProteinsGTP-Regulatory ProteinsGalphaq ProteinGq G-ProteinGq ProteinGq alpha Family G-ProteinGuanineGuanine Nucleotide Coupling ProteinGuanine Nucleotide Exchange FactorsGuanine Nucleotide Exchange ProteinGuanine Nucleotide Regulatory ProteinsGuanine Nucleotide Releasing FactorsGuanosine TriphosphateGuanyl-Nucleotide Exchange FactorGuanyl-Nucleotide Releasing FactorGαq ProteinHeart VascularHeterotrimeric G-ProteinsHeterotrimeric GTP-Binding ProteinsHormonesHybridsHydrolysisImmune systemIntracellular Communication and SignalingIon ChannelIonic ChannelsKinasesKineticsKnowledgeLecithinasesLettersLigand Binding ProteinLigand Binding Protein GeneLigandsM1 receptorMeasuresMediatingMembraneMembrane ChannelsMetabolicMethodsMolecularMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular StereochemistryMuscarinic M1 ReceptorNamesNerve Transmitter SubstancesNervous SystemNeurologic Body SystemNeurologic Organ SystemNeurotransmittersNucleotidesOrganism-Level ProcessOrganismal ProcessPathway interactionsPhospholipasePhosphotransferase GenePhosphotransferasesPhotonsPhysiologic ProcessesPhysiological ProcessesPlayProductivityProtein BindingProtein ConformationProtein DynamicsProteinsRGS Family ProteinRGS ProteinsReceptor ProteinRegulators of G-Protein Signaling ProteinsRetinal S-AntigenRoleSamplingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinStructureTherapeutic HormoneThermodynamicThermodynamicsTimeTransducersTransmissionTransphosphorylasesV2RWorkadenosine 3'5' monophosphatebiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesbound proteincAMPcannabinoid receptor 1cannabinoid receptor type 1cannabinoid type 1circulatory systemcomputational methodologycomputational methodscomputational studiescomputer based methodcomputer methodscomputer studiescomputing methodconformationconformationalconformational stateconformationallyconformationsconstitutive active receptorcryo-EMcryoEMcryogenic electron microscopydrug discoveryexchange factorexperimentexperimental researchexperimental studyexperimentsextracellularinsightmembrane structuremolecular dynamicsmutantnamenamednamingpathwayprotein activationprotein functionreceptorreceptor-mediated signalingsimulationsocial rolestructural determinantsstructural factorssuccesstherapeutic targettransmission process
Description preview
Title
Structural dynamics and energy landscapes of G protein signaling
Project Summary (Abstract)
Extracellular signals like hormones and neurotransmitters use G protein coupled receptors (GPCRs) to activate
multiple signaling pathways inside the cells. GPCR‐mediated signaling is involved in many physiological
processes, making them attractive…
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