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Structural Determinants of Kappa Opioid Receptor Signaling

Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Jul 2021Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025Affective DisordersAgonistAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAntinociceptive AgentsAntinociceptive DrugsArrestinsBehaviorBindingCause of DeathCell Communication and SignalingCell SignalingCessation of lifeChemicalsClinical TreatmentClinical TrialsComplexCryo-electron MicroscopyCryoelectron MicroscopyDataDeathDihydrohydroxycodeinoneDrug TargetingElectron CryomicroscopyG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsG-ProteinsGPCRGTP-Binding ProteinsGTP-Regulatory ProteinsGoalsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHeterotrimeric G-ProteinsHeterotrimeric GTP-Binding ProteinsHuman GenomeIndividualInfumorphIntracellular Communication and SignalingKadianLigandsMS ContinMSirMental DepressionMolecularMolecular InteractionMood DisordersMorphiaMorphineOpiate AntagonistOpiate ReceptorsOpiate agonistOpiate receptor agonistOpiate receptor antagonistOpiatesOpioidOpioid AntagonistOpioid ReceptorOpioid agonistOpioid receptor agonistOpioid receptor antagonistOramorphOramorph SROverdoseOxycodeinonOxycodoneOxycodone SROxycontinPainPain ControlPain TherapyPain managementPainfulPathway interactionsPharmacologyReceptor ActivationReceptor ProteinReceptor SignalingResearchRetinal S-AntigenRoleRoxanolRoxicodoneSignal TransductionSignal Transduction SystemsSignalingSingle Crystal DiffractionStatex SRStructureSystemTherapeuticTransducersX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyabuse liabilityabuse potentialaddictionaddictive disorderantagonismantagonistarrestin Bbeta-arrestinbiological signal transductionclinical interventionclinical therapycryo-EMcryoEMcryogenic electron microscopydepressiondesigndesigningdrug discoveryhuman whole genomein vivoinsightkappa opiatekappa opioidkappa opioid receptorsmu opioid receptorsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypain interventionpain killerpain medicationpain relieverpain sensationpain treatmentpainful sensationpainkillerpathwaypharmacologicreceptorrespiratoryscaffoldscaffoldingside effectsocial rolestructural determinantsstructural factorstrial regimentrial treatmentβ-arrestinκ opiateκ opioidκ opioid receptorsκ-ORκORμ opioid receptorsμ-ORμOR

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Project Summary/Abstract
G protein-coupled receptors (GPCRs) are the largest class of receptors in the human genome and can signal
through multiple transducers, including heterotrimeric G protein and β-arrestins. Opioid receptors are GPCRs
whose role in pain sensation has made them primary drug targets for pain medications such as oxycodone and…

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Structural Determinants of Kappa Opioid Receptor Signaling — WASHINGTON UNIVERSITY | UNITED STATES | Jul 2021 | Dev Procure