grant
Structural definition of CD4-induced HIV-1 Env conformational changes required for infection
NIHUS FederalResearch GrantFY2025AIDSAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeAddressAdoptedAffinityAmino AcidsAntibodiesAntigensApicalArchitectureBindingBiologyBiophysicsBreathingBurialCD4 AntigensCD4 CellsCD4 MoleculeCD4 Positive T LymphocytesCD4 ProteinCD4 ReceptorsCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCellsChargeCryo-electron MicroscopyCryoelectron MicroscopyDataData BasesDatabasesDrug DesignElectron CryomicroscopyEngineering / ArchitectureEnvelope ProteinFundingGlycoproteinsGoalsGrantHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV env Protein gp120HIV-1HIV-1 vaccineHIV-IHIV1HIV1 vaccineHTLV-III gp120Human Immunodeficiency Virus Type 1Human immunodeficiency virus 1HydrophobicityIn SituIndividualInfectionIntervention StrategiesLeadLettersLiteratureMediatingMembraneMembrane FusionMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMotionMovementMutateOKT4 antigenOutputPathway interactionsPb elementPeptide ConformationPeptidesPlayProcessPropertyProtomerReceptor ProteinResistanceResolutionRespiratory AspirationRespiratory InspirationRoleSiteSolventsSourceStretchingStructureSurface CD4 ReceptorsSynthetic antigen binderT4 CellsT4 LymphocytesT4 moleculeTestingTimeVaccinesViralVirusVisualizationaminoacidantibody mimeticsantibody-like binderantibody-like moleculeantibody-like proteinantibody-like reagentbasebasesbiophysical foundationbiophysical principlesbiophysical sciencesbody movementconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydata basedesigndesigningdevelop a vaccinedevelop therapydevelop vaccinesdevelopment of a vaccineenv Antigensenv Gene Productsenv Polyproteinsenv Proteinexpectationexperimentexperimental researchexperimental studyexperimentsgp120gp120 ENV Glycoproteingp120(HIV)heavy metal Pbheavy metal leadhelper T lymphocyte markerhydrophilicityimmunogenimprovedinnovateinnovationinnovativeinspirationintervention developmentlatent HIV reservoirlatent HIV-1 reservoirlatent HIV1 reservoirmembrane structuremovieneutralizing antibodynovelpathwayreceptorreceptor bindingreceptor boundresistantresolutionssocial rolesynthetic antigen binding reagenttherapeutic agent developmenttherapeutic developmenttherapy developmenttreatment developmentvaccine development
Description preview
The HIV-1 envelope glycoprotein (Env), a homotrimer of gp120-gp41 heterodimers, mediates viral entry into
host cells. The gp120 subunit engages host receptors, while the gp41 subunit contains a fusion peptide (FP)
that is inserted into the host membrane to induce host and virus membrane fusion. Prior to its binding to host
receptors, the HIV-1 Env…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click