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Structural biophysics and molecular design in cellular immunity

Organization UNIVERSITY OF NOTRE DAMELocation NOTRE DAME, UNITED STATESPosted 1 May 2016Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AddressBehaviorBindingBiochemistryBiologic ModelsBiological ChemistryBiological ModelsBiologyBiophysicsCell Communication ProcessCell Communication and SignalingCell Mediated ImmunologyCell SignalingCell Signaling ProcessCell-Mediated ImmunityCellular ImmunityCellular ImmunologyComplexElementsEngineered GeneFundingGoalsImmuneImmune mediated therapyImmune responseImmune systemImmunesImmunologically Directed TherapyImmunologyImmunotherapyInstructionIntracellular Communication and SignalingLearningLigandsMHC InteractionMHC ReceptorMajor Histocompatibility Complex ReceptorModel SystemModelingMolecularMolecular ImmunologyMolecular InteractionNIGMSNational Institute of General Medical SciencesOutcomePeptide ReceptorPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeptidesPhysical ChemistryProcessPropertyProtein DynamicsProteinsReceptor ProteinResearchSignal TransductionSignal Transduction SystemsSignalingSpecificitySubcellular Signaling ProcessSystemT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteWorkbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescross reactivitydesigndesigningengineered T cellsgenetically engineered T-cellshost responseimmune system functionimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenicityimmunoresponseimprovedinsightlenslensesmolecular recognitionnew growthnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpMHCpeptide based vaccinereceptorstructural biologysuccessthymus derived lymphocytetransgenic T- cells

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Abstract
Our NIGMS-funded research emphasizes the interface between structural biology, molecular biophysics, and

immunology. Broadly speaking, we aim to connect the fundamental physical principles that govern protein

behavior with function in the immune system, relying on a wide variety of approaches in biophysics, structural

biology,…

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Structural biophysics and molecular design in cellular immunity — UNIVERSITY OF NOTRE DAME | UNITED STATES | May 2016 | Dev Procure