grant
Structural and functional studies of the mycobacterial transcription cycle
Organization ROCKEFELLER UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025ActinobacteriaActinobacteria classActinomycetesAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsBacteriaBasal Transcription FactorBasal transcription factor genesBenemycinBiochemicalBiologicalBiophysicsCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeComplexCouplingCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyDNA SequenceDNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDeathE coliE. coliElectron CryomicroscopyEnzyme GeneEnzymesEscherichia coliFundingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic TranscriptionGenomic DNAGenomicsGenus MycobacteriumHigh G+C Gram-Positive BacteriaIn SituIntracellular Communication and SignalingM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMethodsMiscellaneous AntibioticMolecularMycobacteriumMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionRNA ExpressionRNA Polymerase InhibitorRNA PolymerasesRNA SeqRNA purificationRNA sequencingRNAseqRegulationRegulator GenesRegulonReportingResistance to antibioticsResistant to antibioticsResolutionRibosomesRifadinRifampicinRifampinRimactaneRoleSightSignal TransductionSignal Transduction SystemsSignalingStressStructureSubcellular ProcessTB infectionTB therapyTB treatmentTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription InitiationTranscription factor genesTranscriptional Regulatory ElementsTuberculosisVirulenceVisionanti-microbialantibiotic drug resistanceantibiotic resistantantimicrobialbacteria pathogenbacterial pathogenbiologicbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydisseminated TBdisseminated tuberculosiselectron cryo-tomographyexperimentexperimental researchexperimental studyexperimentsgDNAgenetic trans acting elementgenome scalegenome-widegenomewideglobal healthinfection due to Mycobacterium tuberculosisinterdisciplinary approachmtbmultidisciplinary approachmycobacterialnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyparticlepathogenpathogenic bacteriapleiotropic effectpleiotropismpleiotropyregulatory generesolutionsresponsesocial roletrans acting elementtranscription factortranscriptome sequencingtranscriptomic sequencingtreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathyvisual function
Description preview
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is an ongoing global health crisis. The WHO
reports 10 million active cases and over 1.5 million deaths annually. RNA polymerase (RNAP), the enzyme
responsible for all transcription in bacteria, is the target for rifampicin, a first-line treatment for TB. RNAP is thus
a proven and…
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