grant
Structural Analysis Of Candidate Genes For Type 2 Diabetes and Obesity
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAcinar CellAciner CellsAdipocytesAdipose CellAdultAdult HumanAdult-Onset Diabetes MellitusAffectAffinityAgeAge of OnsetAkimel O'odhamAllelesAllelomorphsAmerican Indian PopulationAmerican Indian groupAmerican Indian individualAmerican Indian peopleAmerican IndiansAmerindianArizonaAssayBMIBMI percentileBMI z-scoreBardet Biedel syndromeBardet-Biedl SyndromeBindingBinding SitesBioassayBiological AssayBirthBirth WeightBody fatBody mass indexC3 aC3aCandidate Disease GeneCandidate GeneCell BodyCell Communication and SignalingCell SignalingCellsChildChild YouthChildhoodChildren (0-21)ClinicalCodeCoding SystemCollaborationsCombining SiteCommunitiesComplement 3aComplement C3aComplexCongenital HyperinsulinismCongenital hyperinsulinemiaDNADNA mutationDataDeoxyribonucleic AcidDevelopmentDiabetes MellitusDiabetes mellitus syndrome in newborn infantDiagnosisDiseaseDisorderDrug TherapyDysfunctionEnzyme GeneEnzymesExocrine pancreasFat CellsFrequenciesFunctional RNAFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGLP-1GPCRGene FrequencyGene TranscriptionGeneralized GrowthGenesGeneticGenetic ChangeGenetic DiversityGenetic TranscriptionGenetic VariationGenetic defectGenetic mutationGenotypeGlp-1GrowthHealthHigh PrevalenceHomology ModelingHumanHumulin RHyperinsulinemiaHyperinsulinemia Hypoglycemia of InfancyHyperinsulinismHypoglycemia of InfancyIGF-Binding Protein 4IGF1RIGF1R geneIGFBP-4ImmunoblottingImpairmentIn VitroIndigenousIndigenous PopulationIndividualInsulinInsulin ResistanceInsulin-Like Growth Factor 1 Receptor GeneInsulin-Like Growth Factor Binding Protein 4Intracellular Communication and SignalingKO miceKetosis-Resistant Diabetes MellitusKnock-out MiceKnockout MiceLeptinLipocytesLipolysisLongitudinal StudiesLow Birth Weight InfantLuciferase ImmunologicLuciferasesMaintenanceMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMeasurementMeasuresMediatingMedical RecordsMiceMice MammalsMissense MutationModern ManMolecular Dynamics SimulationMolecular InteractionMorbid ObesityMurineMusMutationNIDDMNTRK2NTRK2 geneNative PeopleNative-BornNeuropeptidesNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNon-Polyadenylated RNANoncoding RNANoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNontranslated RNANovolin RNull MouseOb Gene ProductOb ProteinObese Gene ProductObese ProteinObesityPHHI HypoglycemiaPI-3K/AKTPI3K/AKTPPARParturitionPathway interactionsPeptidesPeroxisome Proliferator-Activated ReceptorsPersistent Hyperinsulinemia Hypoglycemia of InfancyPersonsPharmacological TreatmentPharmacotherapyPhosphorylationPhysiologicPhysiologicalPhysiopathologyPima IndianPopulationPredispositionPrivatizationProtein PhosphorylationProteinsQuetelet indexRNARNA ExpressionRNA Gene ProductsReactive SiteReceptor ProteinRegular InsulinReportingRibonucleic AcidRiskRisk-associated variantRodentRodentiaRodents MammalsRoleSTAT3STAT3 geneSamplingSevere obesitySignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusStructure-Activity RelationshipSusceptibilityT2 DMT2DT2DMTRKBTherapeuticTissue GrowthTransactivationTranscriptionTribesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnited StatesUntranslated RNAVariantVariationWestern BlottingWestern ImmunoblottingWomanadipogenesisadiposityadult onset diabetesadulthoodagesallelic frequencybiological signal transductionchemical structure functionclinical carecorpulencedevelopmentaldiabetesdrug interventiondrug treatmentearly onsetexocrine pancreaticexomeextreme obesityfat metabolismfetalgenome mutationglucagon-like peptide 1glucose RAglucose metabolismglucose productionglucose rate of appearanceindigenous communityinnovateinnovationinnovativeinsulin resistantinsulin secretioninsulin toleranceketosis resistant diabeteskidsknock-downknockdownlipid biosynthesislipid metabolismlipogenesislong-term studylongitudinal outcome studiesloss of functionlow birth weightlow birthweightlow-frequency mutationmaturity onset diabetesmembermissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmolecular dynamicsneonatal diabetesneonatal diabetes mellitusnon-synonymous mutationnoncodingnonsynonymous mutationnonsynonymous single nucleotide polymorphismnonsynonymous single nucleotide variantnonsynonymous single-nucleotide substitutionnonsynonymous variantnovelontogenyoverexpressoverexpressionpancreas developmentpathophysiologypathwaypediatricpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspopulation basedpostnatalprenatalpromoterpromotorprotective alleleprotective variantprotein blottingprotein functionprototypepublic data basepublic databasepublicly accessible data basepublicly accessible databasepublicly available data basepublicly available databaserare allelerare mutationrare variantreceptorreceptor bindingreceptor boundrisk allelerisk generisk genotyperisk locirisk locusrisk variantsocial rolestructure function relationshiptrans-activationtype 2 DMtype II DMtype two diabetesunbornyoungster
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We have identified several genes that contribute to either T2D or obesity uniquely in an Indigenous population with longitudinal anthropometric and clinical measures of health. For example, missense variants in KCNJ11 and ABCC8, which encode the KIR6.2 and SUR1 subunits of the -cell KATP channel, have previously been implicated in type 2 diabetes,…
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