grant
Striatonigral Microcircuits in Motor Control and Parkinson's Disease
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Basal GangliaBasal NucleiBindingCell BodyCell Communication and SignalingCell SignalingCellsComplexCorpus StriatumCorpus striatum structureDA NeuronDiseaseDisinhibitionDisorderDopamineDopamine neuronDorsalDysfunctionFunctional disorderGene TranscriptionGeneticGenetic TranscriptionGoalsHydroxytyramineImmobilizationIntracellular Communication and SignalingLocomotionMediatingMolecularMolecular InteractionMolecular TargetMotorMovementNerve CellsNerve UnitNeural CellNeurocyteNeuronsParalysis AgitansParkinsonParkinson DiseaseParvalbuminsPathway interactionsPatternPhysiopathologyPrimary ParkinsonismRNA ExpressionReceptor ProteinRegulationRoleSignal TransductionSignal Transduction SystemsSignalingStriate BodyStriatumSubstantia NigraSubstantia nigra structureTranscriptionWorkbiological signal transductionbody movementdopaminergic neuronimaging in vivoin vivo imaginginsightknock-downknockdownlocomotor controlmolecular biomarkermolecular markermotor controlneuronaloptogeneticsorthopedic freezingpathophysiologypathwayreceptorsocial rolestriataltool
Description preview
We used the distinct molecular markers Kremen1 and Calb1 in the dorsal striatum to investigate the roles of direct-pathway striatal projection neuron (dSPN) subtypes in locomotor control. While Calb1+ dSPNs promoted locomotion—consistent with the canonical function of dSPNs—Kremen1+ dSPNs, including those forming patch-like clusters, suppressed…
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