grant
Stress-modified growth signaling in dynamic nutrient environments
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 1 Sept 2020Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026ArchitectureAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBiologic ModelsBiological ModelsBiologyBloodBlood Reticuloendothelial SystemBody TissuesBody partCancer TreatmentCancersCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCell divisionCellsCellular ExpansionCellular GrowthDevelopmentDietDifferentiation and GrowthDiseaseDisorderEngineering / ArchitectureEnsureEnvironmentEssential Amino AcidsFaceFundingFutureGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic TranscriptionGoalsGrowthInflammationInnovative TherapyIntracellular Communication and SignalingKnowledgeLicensingLogicMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMetabolicModel SystemMolecularNutrientNutrient DepletionPathway interactionsProcessProteinsRNA ExpressionRNA-Binding ProteinsRegulatory ProteinSignal TransductionSignal Transduction SystemsSignalingStressSystemT-CellsT-LymphocyteTissue GrowthTissuesTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranslationsUTRsUntranslated RegionsWorkanti-cancer therapybiological signal transductioncancer cellcancer therapycancer-directed therapycell growthcellular differentiationdevelopmentaldietsdrivingfacesfacialgene regulatory networkgenetic regulatory proteinmRNA Translationmalignancyneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathwayprogramsregulatory gene productsensorthymus derived lymphocytetranscription factortranslation
Description preview
PROJECT SUMMARY
Multicellular systems tightly regulate cell division and differentiation. Cells require both signals that license them
to take up the requisite nutrients for these processes as well as detect there is a sufficient environmental nutrient
supply to meet this demand. The cooperation of these two circuits is critical, as metabolic…
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