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Stress and aging: longitudinal evaluation of synaptic changes using in vivo SV2A PET
Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 1 Jun 2025Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025AccelerationAddressAdolescentAdolescent YouthAffectiveAgingAmmon HornAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAreaAutopsyBasic ResearchBasic ScienceBehaviorBehavioralBindingBiologicalBiological AgingBiologyBiometricsBiometryBiostatistical MethodsBiostatisticsBrainBrain Nervous SystemCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesChronicChronic stressClinicClinicalClinical ResearchClinical StudyCognitiveCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalCommon Rat StrainsCornu AmmonisDataDevelopmentDisturbance in cognitionEncephalonEnsureEvaluationExperimental DesignsFive-Year PlansFundingFutureGlycoproteinsGoalsHealth PromotionHippocampusHumanImaging ProceduresImaging TechnicsImaging TechniquesImpaired cognitionIn vivo analysisInvestigationK-AwardsK-Series Research Career ProgramsLongitudinal StudiesMeasuresMediatingMemoryMentorsMentorshipMethodologyMethodsModern ManMolecularMolecular InteractionMorbidityMorbidity - disease ratePETPET ScanPET imagingPETSCANPETTPerformancePhysiologicPhysiologicalPhysiologyPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrefrontal CortexProcessProteinsPsychiatryPsychopathologyR-Series Research ProjectsR01 MechanismR01 ProgramRad.-PETRandomizedRatRats MammalsRattusRecoveryResearchResearch Career ProgramResearch GrantsResearch Project GrantsResearch ProjectsSalutogenesisScanningScientistSpeedStressSynapsesSynapticSynaptic VesiclesTechnologyTestingTimeTracerTrainingTranslational ResearchTranslational Scienceabnormal psychologyadult youthage associatedage associated effectsage correlatedage dependentage effectage groupage linkedage relatedage related effectsage specificaged animalaged animalsaged brainaging associatedaging brainaging effectaging relatedanimal old agebehavior testbehavioral testbench bed sidebench bedsidebench to bed sidebench to bedsidebench to clinicbench to clinical practicebiologicbiological process of agecareercareer developmentcognitive changecognitive dysfunctioncognitive functioncognitive losscognitive performancedecline in functiondecline in functional statusdensitydesigndesigningdevelopmentalelderly animalexperiencefunctional declinefunctional status declinehands on researchhippocampalimage-based methodimaging approachimaging based approachimaging in vivoimaging methodimaging modalityimpact of ageimprovedin vivoin vivo evaluationin vivo imagingin vivo testingindexinginfluence of ageinsightjuvenilejuvenile humanlater in lifelater lifelong-term studylongitudinal outcome studiesmalemedical collegemedical schoolsmodel of animalmolecular imagingmolecule imagingmortalitymulti-modalitymultimodalitynecropsyneural imagingneuro-imagingneuroimagingneurological imagingneuropathologicneuropathologicalneuropathologynovelobject recognitionold animalspositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostmortempre-clinicalpreclinicalprematureprematurityprogramspromoting healthradiolabelradiolabelsradioligandradiotracerrandomisationrandomizationrandomly assignedschool of medicinesocial stigmastigmastress related disordersynapsetranslation researchtranslational investigationyoung adultyoung adult ageyoung adulthood♂
Applications closed.
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PROJECT SUMMARY
This Mentored Research Scientist Career Development Award proposal will be conducted within the
Department of Psychiatry at the Yale School of Medicine, world renown for its commitment to training and
research. This proposal is designed to provide advanced training, expert mentoring, and hands-on research
experience that will…
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