grant
Strategies to Optimize Pig-to-Primate Kidney Xenograft Survival
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Jul 2016Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Ab responseAddressAdoptedAmericanAnimalsAnti-CD20 AntibodyAnti-CD40AntibodiesAntibody FormationAntibody ProductionAntigensB blood cellsB cellB cell repertoireB cellsB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBindingBody TissuesBp35Brain DeadBrain DeathCAR T cellsCAR modified T cellsCAR-TCAR-TsCD154CD19CD19 geneCD20CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD40LCD40LGCarbohydratesCell BodyCell surfaceCellsChronicClinicalComa DepasseDNA AlterationDNA Sequence AlterationDataEquipoiseFailureFamily suidaeFundingGenetic AlterationGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenome engineeringGlycansGraft SurvivalH-D AntigensHanganutziu-Deicher AntigensHeteroantigensHeterogenetic AntigensHeterograftHeterologous AntigensHeterologous TransplantationHeterophil AntigensHeterophile AntigensHumanImmuneImmune responseImmunesImmunobiologyImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunophysiologyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInjuryInjury to KidneyKidneyKidney GraftingKidney TransplantationKidney TransplantsKidney Urinary SystemKnock-outKnockoutLeu-16LifeM mulattaM. mulattaMS4A1MS4A1 geneMS4A2Macaca mulattaMacaca rhesusMediatingModalityModern ManMolecular InteractionNHP modelsOrgan DonorPathway interactionsPatientsPaul-Bunnell AntigensPigsPolysaccharidesPrimatesPrimates MammalsProteinsRecombinant DNA TechnologyRegimenRenal GraftingRenal TransplantationRenal TransplantsRhesusRhesus MacaqueRhesus MonkeyRoleSecondary toSequence AlterationSuidaeSwineT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cells for CART cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-cell therapeuticsT-cell transfer therapyT4 CellsT4 LymphocytesTNFSF5TNFSF5 geneTRAP GeneTacrolimusTechniquesTechnologyTestingTimeTissuesTransgenesTransplantationWait TimeWaiting ListsXenoantigensXenogeneic AntigensXenogenic AntigensXenograftXenograft ModelXenograft procedureXenotransplantationadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyallotransplantallotransplantationanti-CD20antibody biosynthesisantibody rejectionantibody-mediated rejectioncardiac heterograftcardiac xenograftcerebral deathchimeric antigen T cell receptorchimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cellschimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellsclinical relevanceclinical translationclinically relevantclinically translatabledesigndesigningexperiencegenetically engineeredgenome editinggenomic alterationgenomic editingheart heterograftheart xenografthost responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunogenimmunoglobulin biosynthesisimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinjuriesinnovateinnovationinnovativekidney heterograftkidney injurykidney txkidney xenograftnonhuman primate modelsnovelpathwayporcinepreventpreventingrenalrenal heterograftrenal injuryrenal xenograftsocial rolespecies differencesuccesssuidtherapeutic T-cell platformtransgenetransplanttransplant modelwaitlistxeno-transplantxeno-transplantationxenograft transplant modelxenotransplant model
Description preview
PROJECT SUMMARY/ABSTRACT
With thousands of patients now on the waiting list for a kidney transplant, it is obvious that there is a critical
shortage of available donor organs. Xenotransplantation represents a promising solution. This effort is of
paramount importance as a significant number of patients are more likely to die waiting rather than…
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