grant
Sperm tsRNAs/rsRNAs and their RNA modifications in diet-induced epigenetic inheritance
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 9 Aug 2017Deadline 31 May 2029
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult ChildrenAdult DaughtersAdult HumanAdult OffspringAdult SonsAgingBiogenesisBiological FunctionBiological ProcessCell BodyCell LineageCell NucleusCellsCells Placenta-TissueCodeCoding SystemCoinComplexDNA SequenceDataDetectionDevelopmentDietDiseaseDisorderEC 2.1.1EmbryoEmbryo DevelopmentEmbryoblastEmbryogenesisEmbryonicEmbryonic DevelopmentEnvironmental ExposureEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumEventExhibitsFathersFetusFunctional RNAFundingFuture GenerationsGene TranscriptionGenetic TranscriptionGestationHealthHigh Fat DietInflammationInjectionsInner Cell MassInterventionInvestigatorsLate pregnancyMammaliaMammalsMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMemoryMessenger RNAMetabolicMetabolic DiseasesMetabolic DisorderMethodsMethyltransferaseMiceMice MammalsModelingModificationMolecularMouse ES CellMouse ESCMouse Embryonic ProgenitorMouse Embryonic Stem CellsMurineMusNational Institutes of HealthNon-Polyadenylated RNANoncoding RNANontranslated RNANormal PlacentomaNuclearNucleusOnset of illnessOrigin of LifeOutcomePenetrationPhenotypePlacentaPlacenta Embryonic TissuePlacental DevelopmentPlacentationPlacentomePregnancyProcessRNARNA BindingRNA ExpressionRNA Gene ProductsRNA SeqRNA boundRNA sequencingRNAseqRegulationResearchResearch PersonnelResearchersRibonucleic AcidRibonucleoproteinsRibosomal Biogenesis PathwayRibosomal RNARibosomesRoleShapesSiteSmall RNASpecificitySpermSperm HeadSpermatozoaStressThesaurismosisTranscriptionTransfer RNATransmissionTriplet Codon-Amino Acid AdaptorTumor Suppressor Arf Inhibits Ribosomal BiogenesisUnhealthy DietUnited States National Institutes of HealthUntranslated RNAWeightadulthoodbalancebalance functiondevelopmentaldietarydietsdisease onsetdisorder onsetembryo cellenvironmental riskepigeneticallyexperienceinnovateinnovationinnovativeinsightintergenerationalmESCmRNAmetabolic phenotypemetabolism disordermetabotypemethylasemid-pregnancymurine ES cellsmurine ESCmurine embryonic progenitormurine embryonic stem cellnoncodingnoveloffspringpoor dietpreimplantationpreventpreventingprogenitor cell modelprogenitor modelrRNArisk mitigationsexsocial rolesperm cellspermatozoon headstem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modeltRNAtooltraittranscriptome sequencingtranscriptomic sequencingtransfer Ribonucleic acidstransmethylasetransmission processweightszoosperm
Description preview
Project summary:
Increasing lines of evidence in mammals have shown that certain acquired traits during paternal environmental
exposure (e.g., unhealthy diet) can be “memorized” in sperm and transmitted to the future generations without
altering the DNA sequence. Our research seeks to unravel the epigenetic mechanisms by which paternal…
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