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Specialized Translational Control of Stem Cell Differentiation and Embryonic Development
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 15 Mar 2016Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-Kinase5' Untranslated Regions5'UTRAreaAtlasesAttentionBiologicalBiologyBirth DefectsBody TissuesBone marrow failureCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell LineageCell SignalingCellsCellular biologyCleft PalateCodeCoding SystemComplexCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCytoplasmDNA Synthesis FactorDNA mutationDataDevelopmentDevelopmental BiologyDevelopmental GeneDiamond-Blackfan anemiaDiseaseDisorderES cellES cell differentiationESC differentiationElementsEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEndodermEndoderm CellEndodermal CellEndothelial Cell Growth FactorEndowmentEnhancersEpithelial CellsExtracellular Signal-Regulated Kinase GeneExtremitiesFGFFailureFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Regulatory FactorGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneralized GrowthGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGestationGrowthHeterogeneityHumanIndividualIntracellular Communication and SignalingIsoformsLactationLifeLimb structureLimbsLinkMAP Kinase GeneMAPKMPS-1MediatingMesodermMesoderm CellMesodermal CellMessenger RNAMiceMice MammalsMilk ProteinsMitogen-Activated Protein Kinase GeneModern ManMolecular MachinesMurineMusMutationNon-TrunkOrganellesPI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG geneParaxial MesodermPathway interactionsPatternPhenotypePhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePlayPopulationPregnancyProcessProductionProgenitor CellsProtein IsoformsProteinsPseudogenesPtdIns 3-KinaseRNA ExpressionRNA SplicingRPS27RPS27 geneRegulationRegulonResearchRibosomal ProteinsRibosomesRoleSHHSHH geneSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSonic HedgehogSpecific qualifier valueSpecificitySpecifiedSplicingSubcellular SpacesSystemTimeTissue GrowthTissuesTranscriptionTranslatingTranslational RegulationTranslationsType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseVariantVariationWNT Signaling PathwayWNT signalingWorkbiologicbiological signal transductioncell biologycell typecellular differentiationdevelopmentaldifferentiation in embryonic stem cellsembryo derived stem cellembryonal stem cellsembryonic precursor differentiationembryonic progenitorembryonic stem cellembryonic stem cell differentiationfield based datafield learningfield studyfield testfrontiergene regulatory networkgenetic approachgenetic strategygenome mutationgenome scalegenome wide analysisgenome wide studiesgenome-widegenome-wide analysisgenome-wide identificationgenomewidehESChuman ES cellhuman ESChuman embryonic stem cellin vivointerdisciplinary approachlactatinglactationalmRNAmRNA Leader SequencesmRNA Translationmammalian genomemammarymammary gland developmentmammary gland morphogenesismammary morphogenesismultidisciplinary approachneonatenew technologynovelnovel technologiesontogenyparalogparalogous genepathwaypost-natal developmentpostnatal developmentposttranscriptionalpreferenceprogenitorprogenitor biologyprogenitor cell biologyprogenitor cell differentiationprogenitor differentiationprogramsribosomopathysequencing platformsocial rolespatial and temporalspatial temporalspatiotemporalstem and progenitor biologystem and progenitor differentiationstem cell biologystem cell differentiationstem cell of embryonic originstem cellstooltranslation
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Description preview
Control of gene expression in space and time plays an important role in enabling cells to “know” where they are in the
developing embryo and what to become, a process often referred to as cellular specification. Decades of research have
demonstrated numerous layers of regulation in control of gene expression, at both the transcriptional and…
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