grant
Spatiotemporal genomic regulation of disease initiation and progression in pulmonary fibrosis
Organization TRANSLATIONAL GENOMICS RESEARCH INSTLocation PHOENIX, UNITED STATESPosted 1 Jan 2019Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025Airway failureAlveolarArchivesBiologyBlood capillariesBody TissuesCell BodyCell-Extracellular MatrixCellsClinicalDataData SetDiseaseDisease ProgressionDisorderECMEvolutionExtracellular MatrixFibroblastsFibrosing AlveolitisFibrosisFormalinFundingFutureGasesGeneral RadiologyGenesGeneticGenetic DiversityGenetic VariationGenomicsGenotypeHeterogeneityHumanHypoxiaHypoxicIndividualLinkLungLung ParenchymaLung Respiratory SystemLung TissueLung Tissue FibrosisMediatingModern ManMolecularMorbidityMorbidity - disease rateNatural HistoryOutcomeOxygen DeficiencyParaffin EmbeddingPathogenesisPathologicPathway interactionsPatientsPositionPositioning AttributePrecision therapeuticsPrimary PreventionProductionPulmonary FibrosisRadiographyRadiologyRadiology SpecialtyRegulationRespiratory FailureRoentgenographyRoleSamplingSecondary PreventionSeveritiesStructure of parenchyma of lungSurfaceSyndromeTechnologyTherapeuticTissue SampleTissuesWorkadvanced diseaseadvanced illnesscapillarycell typediffuse interstitial pulmonary fibrosisend stage diseasefibrosis in the lungidiopathic pulmonary fibrosisinsightlung fibrosismolecular pathologymortalitynovelpathwaypre-clinicalprecision therapiesprecision treatmentpreclinicalprimary outcomeprogramsradiological imagingscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial and temporalspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial temporalspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspatiotemporaltargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptomics
Description preview
PROJECT SUMMARY
During the prior funding period, we established a single-cell transcriptomic dataset of >50 idiopathic pulmonary
fibrosis (IPF) and >70 non-fibrotic control lungs, through which we defined multiple previously unrecognized
and/or disease-emergent cell types and states in the human lung. These studies have provided substantial
new…
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