grant
Spatially Resolved Molecular Measurement of Biomolecular Condensates
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 3 Apr 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025AdoptedAffectAffinityAgingBindingBinding ProteinsBiologic ModelsBiologicalBiological ModelsBiologyBody TissuesCell AgingCell BodyCell Communication and SignalingCell FractionCell FunctionCell NucleolusCell NucleusCell PhysiologyCell ProcessCell SenescenceCell SignalingCellsCellular AgingCellular FunctionCellular PhysiologyCellular ProcessCellular SenescenceChromatinCommunitiesComputational toolkitCytoplasmCytoplasmic GranulesDNADataData AnalysesData AnalysisDeoxyribonucleic AcidDevelopmentDiseaseDisorderEngineeringEnsureEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEukaryotic CellEventFibroblastsGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGenerationsGenomeGenome LibraryGenomic LibraryGenomicsGermGoalsHealthHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHousekeepingHouseworkHumanHybridsIn SituIntracellular Communication and SignalingLabelLaser ElectromagneticLaser RadiationLasersLigand Binding ProteinLigand Binding Protein GeneLinkLocationMachine LearningMeasurementMembraneMethodsModalityModel SystemModern ManMolecularMolecular FingerprintingMolecular InteractionMolecular ProfilingNoiseNon-Polyadenylated RNANuclearNucleusOrganellesPathologicPathologyPhysical condensationPhysiologicPhysiologicalPhysiologyPlasmosomePlayPost-Transcriptional ControlPost-Transcriptional RegulationProcessProtein BindingRNARNA Gene ProductsRNA metabolismReactionRegulatory ElementReplicative SenescenceResearchResolutionRibonucleic AcidRoleSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessTechnologyTissuesTn5 transposaseVHHVHH antibodyWorkaging associatedaging relatedbiologicbiological adaptation to stressbiological signal transductionbound proteincamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaincell typecomputational pipelinescomputational toolboxcomputational toolscomputational toolsetcomputerized toolscondensationdata acquisitiondata acquisitionsdata interpretationdesigndesigningdevelopmentalepigeneticallyepigenomeepigenomicsgene manipulationgenetic manipulationgenetically manipulategenetically perturbgenomic platformgenomic toolsglobal gene expressionglobal transcription profilegranulehigh throughput technologyhistone modificationimprovedinnovateinnovationinnovativeinsightlenslensesmachine based learningmembrane structuremolecular imagingmolecular profilemolecular signaturemolecule imagingmulti-modalitymultimodalitynanobodiesnanobodynext generationnovelnucleoluspost-transcriptional gene regulationreaction; crisisrecruitreplicative agingresolutionssdAbsequencing platformsingle domain antibodiessocial rolestress granulestress responsestress; reactionsub micronsubmicrontooltranscriptometranscriptomicsuptakevariable heavy chain antibody
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PROJECT SUMMARY
Biomolecular condensates are diverse and abundant membrane-less organelles that partition the intracellular
environment into functionally distinct compartments containing specific sets of molecules and reactions.
Biomolecular condensates participate in various essential housekeeping, stress-response, or cell type-specific…
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