grant
Spatially Resolved, Functional Dissection of the Human Spermatogonial Stem Cell Niche
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 4 Apr 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025Basic ResearchBasic ScienceBody TissuesC-KIT GeneCD117CD117 AntigensCancer PatientCancersCannot achieve a pregnancyCatalogsCausalityCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsClinicComparative StudyCoupledDNA Synthesis FactorDataData SetDifficulty conceivingDissectionEDN1EPLG1ET-1Eck LigandEck RPTK LigandEndothelial Cell Growth FactorEndothelinEndothelin Type 1Endothelin-1Endothelium Secreted Protein B61Endothelium-Derived Vasoconstrictor FactorsEph Receptor LigandsEphrin-A1EphrinsEpl1 ProteinEtiologyFGFFGF ReceptorsFGF-RFGFRFecundabilityFecundityFertilityFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Factor Receptor FamilyFibroblast Growth Factor ReceptorsFibroblast Growth Regulatory FactorFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoundationsGDNFGDNF geneGametesGene ExpressionGenetic ModelsGerm CellsGerm-Line CellsGoalsHealth CareHeterograftHeterologous TransplantationHumanIn VitroIndividualInfertilityIntracellular Communication and SignalingKnowledgeLERK-1 ProteinLigandsMale InfertilityMalignant NeoplasmsMalignant TumorMapsMast Cell Growth Factor ReceptorMediatingMiceMice MammalsModelingModern ManMolecularMolecular AnalysisMurineMusNon-Polyadenylated RNAPatientsProcessProductionProgenitor CellsProto-Oncogene Protein c-kitRNARNA Gene ProductsReceptor ProteinReceptor SignalingRegulationReproductive CellsResearchRibonucleic AcidRodentRodentiaRodents MammalsRoleSCF ReceptorSCF Receptor GeneSCFRSeriesSex CellSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSomatic CellSperm stem cellSpermatogenesisStem Cell Factor ReceptorStem Cell Factor Receptor GeneSystemTesticlesTestingTestisTherapeuticTissuesTranslatingWorkXenograftXenograft procedureXenotransplantationbiological signal transductionc kitc-kit Proteinc-kit Receptorcatalogcausationcell typecomparativedisease causationfertility cessationfertility lossfertility preservationflow cytophotometrygenome scalegenome-widegenomewideglial cell-line derived neurotrophic factorhuman adult stem cellin vivoinfertileinfertile malesinfertile meninfertility in meninitial cellinsightkit Proto-Oncogene Proteinlife spanlifespanmalemale factor infertilitymalignancymen facing infertilitymen with infertilitymethod developmentmouse modelmurine modelneoplasm/cancerneurturinnew approachesnovelnovel approachesnovel strategiesnovel strategynrtn proteinp145(c-kit)p145c-kitpreserve fertilityprogenitor cell expansionprogenitor cell functionprogenitor cell nicheprogenitor cell regenerationprogenitor cell self renewalprogenitor expansionprogenitor functionprogenitor nicheprogenitor regenerationprogenitor self renewalreceptorreceptor-mediated signalingreproductiveself-renewself-renewalsexual cellsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssperm progenitorspermatogonia cellspermatogonia progenitorspermatogonia stem cellsspermatogonial cellspermatogonial progenitorspermatogonial stem cellsstem and progenitor cell expansionstem and progenitor cell functionstem and progenitor cell nichestem and progenitor cell regenerationstem and progenitor cell self renewalstem and progenitor functionstem cell approachstem cell based approachstem cell expansionstem cell functionstem cell methodstem cell methodologystem cell nichestem cell procedurestem cell regenerationstem cell self renewalstem cell techniquestem cellstoolxeno-transplantxeno-transplantation♂
Description preview
PROJECT SUMMARY
The functions of human spermatogonial stem cells (SSCs), including self-renewal and differentiation, are
required for the constant production of male gametes over a long reproductive lifespan; imbalances in this
process directly contribute to infertility or germ cell-derived cancers. Despite this wide range of healthcare…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click