grant
Spatial Multi-omic Analysis of HIV-infected Cell Reservoirs in the Tumor Microenvironment
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressBiologyCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell SurvivalCell ViabilityCellsCustomDNADeoxyribonucleic AcidDetectionEXTMREngineeringExpression SignatureExtramuralExtramural ActivitiesFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene ExpressionGene Expression ProfileGerminoblastic SarcomaGerminoblastomaGoalsHIVHuman Immunodeficiency VirusesIn VitroLAV-HTLV-IIILinkLymphadenopathy-Associated VirusLymphatic TissueLymphoid TissueLymphomaMalignant LymphomaMicroanatomyMicrofluidic DeviceMicrofluidic Lab-On-A-ChipMicrofluidic MicrochipsMicroscopic AnatomyPersonsRestReticulolymphosarcomaSeriesT4 CellsT4 LymphocytesTumor CellVaccine ResearchVirusVirus ReplicationVirus-HIVantiretroviral therapyantiretroviral treatmentcancer microenvironmentco-morbidco-morbiditycomorbiditycustomsflow cytophotometrygene expression patterngene expression signatureglobal gene expressionglobal transcription profilein vivoinsightmemory CD4 T cellmemory CD4 T lymphocytemicrofluidic chipneoplastic cellnew technologynovel technologiesnucleic acid detectionspatial multiomicsspatial omicsspatial tri-omicstranscriptional profiletranscriptional signaturetranscriptometranscriptomicstumor microenvironmentvaccine-related researchviral multiplicationviral replicationvirus multiplication
Description preview
The Vaccine Research Center (VRC) Virus Persistence and Dynamics Section (VPDS) seeks to address barriers to HIV cure by developing and applying new technologies that comprehensively describe the biology of HIV-infected cell reservoirs. Although resting memory CD4 T cells harboring HIV DNA under antiretroviral therapy (ART) have for decades been…
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