grant
Spatial and Temporal Tracking of Neural Stem Cells Migration to Brain Metastases of Breast Cancer using High Resolution Imaging
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Dec 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2025Animal ModelAnimal Models and Related StudiesAntibodiesBehaviorBlood - brain barrier anatomyBlood-Brain BarrierBody TissuesBrainBrain DiseasesBrain DisordersBrain MetastasisBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsBreast CancerBreast MetastasisCNS Nervous SystemCancersCell BodyCell CommunicationCell InteractionCell secretionCell-to-Cell InteractionCellsCellular SecretionCentral Nervous SystemClinical TrialsComplexContrast AgentContrast DrugsContrast MediaCranial IrradiationDataDevelopmentDiagnosisERBB2ERBB2 geneEncephalonEncephalon DiseasesEngraftmentEnsureEnvironmentExperimental Animal ModelExperimental ModelsGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHER -2HER-2HER2HER2 GenesHER2/neuHemato-Encephalic BarrierImageImaging ProceduresImaging TechnicsImaging TechniquesIn VitroIncidenceInjectionsIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvadedInvestigatorsKineticsKnowledgeLabelLaboratoriesLesionLigandsMR ImagingMR TomographyMRIMRIsMagnetic ResonanceMagnetic Resonance ImagingMalignant Breast NeoplasmMalignant CellMalignant NeoplasmsMalignant TumorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the BrainMetastatic TumorMetastatic Tumor to the BrainMetastatic malignant neoplasm to brainMethodologyMethodsMiceMice MammalsMicroscopeModelingMonitorMultimodal ImagingMurineMusNEU OncogeneNEU proteinNMR ImagingNMR TomographyNeoplasm MetastasisNeural DevelopmentNeural Stem CellNeuraxisNeuroglial NeoplasmNeuroglial TumorNuclear Magnetic Resonance ImagingOncogene ErbB2Operative ProceduresOperative Surgical ProceduresOrganPETPET ScanPET imagingPETSCANPETTPatientsPermeabilityPhotonsPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPre-Clinical ModelPreclinical ModelsPreclinical dataProgenitor CellsPrognosisPropertyProtocolProtocols documentationRad.-PETRadiation therapyRadiopaque MediaRadiotherapeuticsRadiotherapyReceptor ProteinRecommendationResearch PersonnelResearchersResolutionRouteSPECTSPECT imagingSecondary NeoplasmSecondary TumorSingle-Photon Emission-Computed Radionuclide TomographySolidSolid NeoplasmSolid TumorStem Cell likeSurgicalSurgical InterventionsSurgical ProcedureSystemTKR1TherapeuticTherapeutic EffectTherapeutic antibodiesTissuesTranslationsTropismValidationWomanWorkZeugmatographybloodbrain barrierbrain basedbrain irradiationbrain micrometastasisbrain parenchymabrain radiationbreast cancer metastasisc-erbB-2c-erbB-2 Genesc-erbB-2 Proto-Oncogenescancer cellcancer metastasiscell behaviorcellular behaviorchemotherapeutic agentchemotherapeutic compoundschemotherapeutic drugschemotherapeutic medicationschemotherapycompound eyecranial radiationdesigndesigningdevelopmentalerbB-2 Genesglial-derived tumorglioblastoma multiformeherstatinhigh resolution imagingimage-based methodimagingimaging agentimaging approachimaging based approachimaging methodimaging modalityimaging platformimmunogenicityimprovedin vivoinstrumentationinterestmalignancymalignant breast tumormigrationmodel of animalmulti-modal imagingmulti-modality imagingmultimodality imagingnano particlenano-sized particlenanoparticlenanosized particleneoplasm/cancernerve stem cellneu Genesneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurodevelopmentneurogenic progenitorsneurogenic stem cellneuroglia neoplasmneuroglia tumorneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-invasive imagingnoninvasive imagingnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalpre-clinical studypreclinicalpreclinical findingspreclinical informationpreclinical studyprogenitor and neural stem cellsprogenitor biologyprogenitor capacityprogenitor cell based therapyprogenitor cell biologyprogenitor cell fateprogenitor cell likeprogenitor cell migrationprogenitor cell therapyprogenitor cell treatmentprogenitor fateprogenitor migrationprogenitor therapyprogenitor treatmentprogenitor-likeradiation treatmentreceptorresolutionsside effectsingle photon emission computed tomographysite targeted deliveryspatial and temporalspatial temporalspatial temporal imagingspatial temporal mappingspatiotemporalspatiotemporal imagingspatiotemporal mappingspongioblastoma multiformestem and progenitor biologystem and progenitor cell fatestem and progenitor cell therapystem cell based therapystem cell biologystem cell characteristicsstem cell fatestem cell mediated therapystem cell migrationstem cell therapeuticsstem cell therapystem cell treatmentstem cell-based therapeuticstem cell-based treatmentstem cellsstem-likestemnesssurgerytargeted deliverytherapeutic evaluationtherapeutic testingtranslationtreatment with radiationtumortumor cell metastasistumors in the brainuptakevalidations
Get Agency plan to apply$29.99/mo · 7-day free trial · pipeline · alerts
or
— or —Get email alerts for similar roles
Description preview
PROJECT SUMMARY
Patients diagnosed with breast cancer brain metastases (BM) have a poor prognosis, and their
therapeutic options are minimal. Surgical intervention is limited to a single lesion, whereas most women present
with multiple metastases, and most chemotherapeutic drugs are not effective due to the blood-brain barrier.
Whole-brain…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click