grant
Southwest EDRN Clinical Validation Center for Head and Neck Cancer
Organization ARIZONA STATE UNIVERSITY-TEMPE CAMPUSLocation SCOTTSDALE, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20252019-nCoV vaccine7S Gamma GlobulinAcademic Medical CentersAddressAgeAntibodiesAreaArizonaAssayBackBindingBioassayBiological AssayBiological MarkersBlindedBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SerumCOVID assayCOVID-19COVID-19 assayCOVID-19 vaccineCOVID19 assayCV-19Cancer CauseCancer ControlCancer Control ScienceCancer EtiologyCancer InductionCancer PatientCaringCervical CancerCervical Cancer ScreeningCervix CancerClinicalClinical EvaluationClinical ManagementClinical ResearchClinical StudyClinical TestingCollaborationsCollectionControlled Clinical TrialsCoronavirus Infectious Disease 2019DNADataDeoxyribonucleic AcidDetectionDevelopmentDiagnosisDiagnosticDorsumDrynessEDRNELISAEarly Detection Research NetworkEarly DiagnosisEnrollmentEnzyme-Linked Immunosorbent AssayFeasibility StudiesFingersFoundationsFundingGenderGeneral PopulationGeneral PublicGeographic AreaGeographic LocationsGeographic RegionGeographical LocationGoalsHNSCCHPVHPV + oropharyngeal carcinomaHPV 16HPV VaccinationHPV associated HNSCCHPV caused cancerHPV driven HNSCCHPV driven cancersHPV driven head and neck cancerHPV induced cancerHPV malignancyHPV mediated oropharynx cancerHPV oropharyngeal cancerHPV positiveHPV positive oropharyngeal cancerHPV positive oropharynx cancerHPV related oropharyngeal cancerHPV related oropharyngeal carcinomaHPV screeningHPV(+)HPV(+) HNSCCHPV(+) head and neck squamous cell carcinomaHPV+HPV+ HNSCCHPV+ OPCHPV+ cancerHPV+ head and neck cancersHPV+ oropharyngeal cancerHPV-16HPV-OPCHPV-Related MalignancyHPV-associated cancerHPV-associated head and neck cancerHPV-associated head and neck squamous cell carcinomaHPV-associated malignancyHPV-associated oropharyngeal cancerHPV-driven oropharyngeal cancerHPV-positive HNSCCHPV-positive head and neck cancersHPV-related HNSCCHPV-related OPCHPV-related cancerHPV-related head and neck squamous cell carcinomaHPV-related oropharyngeal cancerHPV16Head and Neck CancerHead and Neck CarcinomaHead and Neck Squamous Cell CarcinomaHigh Risk WomanHomeHumanHuman Papilloma VirusHuman Papilloma Virus VaccinationHuman Papilloma Virus screeningHuman Papilloma Virus-Related MalignancyHuman Papilloma Virus-Related Malignant NeoplasmHuman Papilloma Virus-associated cancerHuman Papilloma Virus-associated malignancyHuman Papilloma Virus-related cancerHuman PapillomavirusHuman Papillomavirus VaccinationHuman papilloma virus type 16Human papillomavirus 16Human papillomavirus cancerHuman papillomavirus driven HNSCCHuman papillomavirus driven head and neck cancerHuman papillomavirus driven oropharyngeal cancerHuman papillomavirus induced cancerHuman papillomavirus malignancyHuman papillomavirus related oropharyngeal carcinomaHuman papillomavirus type 16Human papillomavirus- related oropharyngeal cancerHuman papillomavirus-Related MalignancyHuman papillomavirus-Related Malignant NeoplasmHuman papillomavirus-associated oropharyngeal cancerIgGImmuneImmunesImmunoglobulin GIncidenceIndividualInfectionInfectious Human Wart VirusInfrastructureLaboratoriesMalignant Cervical NeoplasmMalignant Cervical TumorMalignant Head and Neck NeoplasmMalignant Neoplasm of the CervixMalignant Oropharyngeal NeoplasmMalignant Oropharyngeal TumorMalignant Tumor of the CervixMalignant Tumor of the Cervix UteriMalignant Uterine Cervix NeoplasmMalignant Uterine Cervix TumorMalignant neoplasm of cervix uteriMethodologyMethodsModern ManMolecular InteractionMorbidityMorbidity - disease rateNational Detection Research NetworkNewly DiagnosedNucleic Acid Amplification TestsNucleic Acid TestingNucleic AcidsOncogene ProductsOncogene ProteinsOncoproteinsOral healthOropharnyx CancersOropharyngealOropharyngeal CancerOropharyngeal CarcinomaOropharynxOropharynx CancerOropharynx CarcinomaOropharynxsParticipantPatientsPeer Review GrantsPerformancePhasePhase 3 Clinical TrialsPhase III Clinical TrialsPlasmaPlasma SerumPopulationPredicting RiskPredictive ValuePrevalenceProspective StudiesPublicationsReagentRecurrent Malignant NeoplasmRecurrent Malignant TumorResearchResearch DesignResearch InstituteResearch ResourcesResearch SpecimenResourcesReticuloendothelial System, Serum, PlasmaRiskRisk AssessmentSARS-CoV-2 assaySARS-CoV-2 vaccineSARS-coronavirus-2 vaccineSCCHNSalivaSalivarySamplingSchool DentistriesSchool DentistryScientific PublicationScreening for cancerSerologySerology testSerumSevere Acute Respiratory Syndrome CoV 2 vaccineSevere acute respiratory syndrome coronavirus 2 vaccineSpecimenSpeedSpottingsStudy TypeSystemTechnologyTestingTexasUniversitiesUniversity Medical CentersUterine Cervix CancerValidationViraladvanced diseaseadvanced illnessagesaggressive therapyaggressive treatmentanti-cancer researchassay developmentat-risk femalesat-risk womenbio-markersbiobankbiologic markerbiomarkerbiomarker developmentbiomarker performancebiomarker utilitybiomarker validationbiorepositoryblood-based biomarkerblood-based markercancer biomarkerscancer markerscancer preventioncancer recurrencecancer researchcarcinogenesiscervical cancer early detectioncervical screeningcirculating biomarkerscirculating markersclinical applicabilityclinical applicationclinical testclinical validationcohortcomparativecoronavirus disease 2019coronavirus disease 2019 assaycoronavirus disease 2019 vaccinecoronavirus disease assaycoronavirus disease-19coronavirus disease-19 vaccinecoronavirus infectious disease-19dental healthdepositorydesigndesigningdevelopmentaldigitalearly cancer detectionearly detectionenrollenzyme linked immunoassayexperiencefeasibility testingfemales at high riskforecasting riskgeographic sitehead and neck squamous carcinomahead and neck squamous cell cancerhead/neck cancerhigh risk femaleshomeshuman papilloma virus 16human papilloma virus+ head and neck squamous cell carcinomahuman papillomavirus +human papillomavirus associated head and neck cancerhuman papillomavirus associated head and neck squamous cell carcinomahuman papillomavirus associated malignancyhuman papillomavirus caused cancerhuman papillomavirus driven cancershuman papillomavirus driven head and neck squamous cell carcinomahuman papillomavirus induced head and neck squamous cell carcinomahuman papillomavirus mediated oropharynx cancerhuman papillomavirus positivehuman papillomavirus positive HNSCChuman papillomavirus positive head and neck cancershuman papillomavirus positive head and neck squamous cell carcinomahuman papillomavirus positive oropharyngeal cancerhuman papillomavirus positive oropharyngeal carcinomahuman papillomavirus positive oropharynx carcinomahuman papillomavirus related head and neck squamous cell carcinomahuman papillomavirus+ oropharyngeal cancerhuman papillomavirus-associated cancerhuman papillomavirus-related cancerimmunogenicityimprovedinnovateinnovationinnovativeinstrumentmalignant head and neck tumormalignant oropharynx neoplasmmalignant oropharynx tumormarker validationmenmigrationmortalitynCoV vaccinenCoV-19 vaccinenCoV19 vaccinenoveloperationoperationsoral HPV-positive HNSCCoral HPV-positive head and neck cancersoral human papillomavirus positive head and neck cancersoral human papillomavirus positive head and neck squamous cell carcinomaoral pharyngealpatient populationperipheral bloodphase III protocolprecancer cervical detectionpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskpresence of HPVpresence of human papillomavirusprogramsprospectivepublic health prioritiesrepositoryresearch clinical testingresponserisk predictionrisk predictionssaliva assaysaliva based assaysaliva based testsaliva diagnosticsaliva samplesaliva testsalivary assaysalivary diagnosticssalivary samplesalivary testsample collectionscreeningscreening cancer patientsscreening programscreeningsserological markerserology assaysevere acute respiratory syndrome coronavirus 2 assayspecimen collectionstudy designsuccesstype 16 Human papilloma virustype 16 Human papillomavirusunder served communityunderserved communityvaccine against 2019-nCovvaccine against COVID-19vaccine against SARS-CoV-2vaccine against SARS-coronavirus-2vaccine against Severe Acute Respiratory Syndrome CoV 2vaccine against Severe acute respiratory syndrome coronavirus 2vaccine candidates against SARS-CoV-2vaccine for novel coronavirusvaccines preventing COVIDvaccines to prevent COVIDvalidation studiesvalidationswart viruswomen at high risk
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Project Summary/Abstract
The goal of the EDRN Southwest Clinical Validation Center for Head and Neck Cancer is to improve oropharyngeal cancer
screening through the rigorous validation of salivary biomarkers. The scientific approach of our Center is based on several
fundamental principles. First, that human papillomaviral (HPV) infection and…
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