grant

Sonogenetics 2.0

Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 15 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253-D print3-D printer3D Print3D printer3D printingAAV vectorAAV-based vectorAcousticsAddressAdeno-Associated VirusesAnimalsAreaBenchmarkingBest Practice AnalysisBiologicalBiomedical EngineeringBody TissuesBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain regionCell FunctionCell PhysiologyCell ProcessCell membraneCellular FunctionCellular PhysiologyCellular ProcessCollaborationsCommunitiesCorpus StriatumCorpus striatum structureCytoplasmic MembraneD1 receptorDataDependoparvovirusDependovirusDevelopmentDevice DesignsDevicesDopamine D1 ReceptorDrug DeliveryDrug Delivery SystemsEncephalonEncephalon DiseasesEngineeringExhibitsFocused UltrasoundGene DeliveryGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetics-MutagenesisGoalsHumanInjectionsIntracranial CNS DisordersIntracranial Central Nervous System DisordersIntranasal AdministrationIntranasal Drug AdministrationInvestigationInvestigatorsIon ChannelIonic ChannelsIonsLaboratoriesLightLocationMediatingMembrane ChannelsMiceMice MammalsMicrobubblesModalityModern ManMolecular ProbesMotorMsecMurineMusMutagenesisMutagenesis Molecular BiologyNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesNeurosciences ResearchOperative ProceduresOperative Surgical ProceduresPenetrationPerformancePhotoradiationPlasma MembranePopulationProcessPropertyPublic HealthPublishingR-Series Research ProjectsR01 MechanismR01 ProgramRecombinant DNA TechnologyResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersResolutionRodentRodentiaRodents MammalsSafetySerotypingSonicationStriate BodyStriatumStructureSubcellular ProcessSurgicalSurgical InterventionsSurgical ProcedureTRPV1TRPV1 geneTechniquesTechnologyTissuesTransducersTranslatingUltrasonicUltrasonic TransducerUltrasonicsUltrasound transducerValidationVariantVariationViral Vectoradeno associated virus groupadeno-associated viral vectoradeno-associated virus vectorbenchmarkbio-engineeredbio-engineersbioengineeringbiologicbiological engineeringbrain controlcell typedetermine efficacydevelopmentalefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyfree behaviorgene manipulationgenetic manipulationgenetically engineeredgenetically manipulategenetically perturbimprovedinfancyinfantileinnovateinnovationinnovativelenslensesmillisecondmotor controlmultidisciplinarymutantneuralneural circuitneural circuitryneural controlneural regulationneurocircuitryneuromodulationneuromodulatoryneuronalneuroregulationnext generationoptogeneticsplasmalemmaresolutionsresponsestriatalsurgerysynaptic circuitsynaptic circuitrytech developmenttechnology developmentthree dimensional printingtooltransient receptor potential cation channel V1translational opportunitiestranslational potentialultrasoundultrasound energyvalidationswearablewearable devicewearable electronicswearable systemwearable technologywearable toolwearables
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PROJECT SUMMARY/ABSTRACT
Achieving noninvasive, cell-type-specific, and spatially precise neuromodulation remains to be a major

challenge in the development of neuromodulation technologies. The objective of this project is to develop

Sonogenetics 2.0, the next-generation sonogenetic technique for cell-type-specific, spatially precise…

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