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Social control of lifespan regulation via glial plasticity in ants
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 Apr 2021Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAcquired brain injuryAdultAdult HumanAgeAge associated cognitive deficitAge associated cognitive dysfunctionAge related memory declineAge related memory deficitAge related memory impairmentAge-associated cognitive declineAge-related cognitive declineAgingAntibodiesAntsApoptosisApoptosis PathwayAssayAutoregulationBehaviorBenign senescent forgetfulnessBioassayBiologic ModelsBiologicalBiological AssayBiological ModelsBrainBrain InjuriesBrain Nervous SystemBrain regionCandidate Disease GeneCandidate GeneCastesCell BodyCell Communication and SignalingCell SignalingCellsDataDrosophilaDrosophila genusEncephalonEventExpression SignatureFamilyFluorescence Light MicroscopyFluorescence MicroscopyGene Expression ProfileGene TranscriptionGenesGeneticGenetic TranscriptionGenomeGliaGlial CellsGoalsHomeostasisHousekeepingHouseworkIn VitroIncrease lifespanInsectaInsectsInsects InvertebratesIntracellular Communication and SignalingKolliker's reticulumLDLLDL LipoproteinsLength of LifeLifeLigandsLinkLongevityLow-Density LipoproteinsMammaliaMammalsMeasuresModel SystemModelingMolecularNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuron DegenerationNeuronal InjuryNeuronsNeuropilNon-neuronal cellNonneuronal cellPathway interactionsPhagocytesPhagocytic CellPhenotypePhysiological HomeostasisPhysiologyPlayPopulationProcessProgrammed Cell DeathProliferatingPropertyRNA ExpressionReceptor ProteinRecombinantsRegulationReproductionRoleSignal TransductionSignal Transduction SystemsSignalingSocial ControlsSocial statusSortingTestingTranscriptionVisualizationVitellogeninsWorkadulthoodage associatedage associated cognitive impairmentage associated memory declineage associated memory deficitage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage correlatedage dependentage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage linkedage relatedage related cognitive deficitage related cognitive dysfunctionage related cognitive impairmentage related memory dysfunctionage related neurodegenerationage specificage-associated memory impairmentage-driven neurodegenerative disordersage-induced cognitive declineage-related decline in cognitionage-related decline in cognitive functionage-related neurodegenerative diseaseage-related neurodegenerative disorderagedaged brainagesaging associated neurodegenerationaging associated neurodegenerative diseaseaging brainaging induced epigenetic changeaging related cognitive declineaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderaging-associated epigenetic changeaging-related epigenetic changeamebocytebeta-Lipoproteinsbiologicbiological signal transductionboost longevitybrain damagebrain healthbrain injury responsebrain-injureddefined contributionelongating the lifespanenhance healthspanenhance longevityepigenetic agingepigenetic mechanisms in agingepigenetic modifications in agingepigenetic regulation of agingexperimentexperimental researchexperimental studyexperimentsextend healthspanextend life spanextend lifespanextend longevityextending healthy lifespanfoster longevityfruit flygene expression patterngene expression signaturegene manipulationgenetic manipulationgenetically manipulategenetically perturbhealthspan extensionhealthy aginghealthy human agingimprove healthspanimprove lifespanimprove longevityin vivoincrease healthspanknock-downknockdownlife spanlifespanlifespan extensionnerve cementneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuron injuryneuronalneuronal degenerationneuroprotectionneuroprotectiveold agepathwayprolong healthspanprolong lifespanprolong longevitypromote healthspanpromote lifespanpromote longevityreceptorreproductiveresponseresponse to brain injuryscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocialsocial positionsocial rolesocial standingsupport longevitytooltranscriptional profiletranscriptional signature
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ABSTRACT
Age-related neurodegenerative diseases pose an immense biomedical challenge. Plastic changes in the brain
underpin aging-related cognitive decline and neurodegeneration but little is known about the neuroprotective
pathways that forestall these processes in healthy aging brains. In mammals, glia composition and
properties display…
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