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SMART BIOELECTRONIC IMPLANTS FOR CONTROLLED DELIVERY OF THERAPEUTIC PROTEINS IN VIVO AND ITS APPLICATION IN LONG-TERM TREATMENT OF HEMOPHILIA A

Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 1 May 2022Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025AddressAllogenicAmericanAnimal ModelAnimal Models and Related StudiesAntihemophilic FactorBeta CellBiocompatible MaterialsBiologicalBiomaterialsBiomedical EngineeringBiotechBiotechnologyBlood Coagulation Factor VIIICapsulesCell BodyCell ComponentsCell FunctionCell LineCell PhysiologyCell ProcessCell StructureCell SurvivalCell TherapyCell TransplantationCell ViabilityCell secretionCellLineCellsCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessCellular SecretionCellular StructuresChinaChronicChronic DiseaseChronic IllnessClinicalCoagulation Factor VIIICoagulation Factor VIIIcD-GlucoseDevelopmentDevice DesignsDevicesDextroseDiabetes MellitusDiseaseDisorderDoseDrug DeliveryDrug Delivery SystemsDrug ModulationDrug TargetingDrugsEconomicsElectronicsElementsEmergent TechnologiesEmerging TechnologiesEncapsulatedEngineeringEnsureFactor VIIIFactor VIII DeficiencyFactor VIII F8BFibrosisForeign BodiesForeign-Body ReactionFrustrationGasesGene ActivationGenerationsGeneticGlucoseGraft SurvivalH+ elementHemophiliaHemophilia AHepatic DisorderHeterograftHeterologous TransplantationHumanHuman EngineeringHybrid CellsHydrogen IonsHypoxiaHypoxicImmuneImmune responseImmune systemImmunesImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImplantIn SituInflammationInsulin CellInsulin Secreting CellLightLiver diseasesMainland ChinaMaintenanceMedicationMedicineMembraneMiceMice MammalsMicrocapsules drug delivery systemMicrofabricationModelingModern ManModificationMonitorMurineMusNatureNutrientO elementO2 elementOpticsOxygenOxygen DeficiencyPermeabilityPharmaceutical PreparationsPhotoradiationPopulationPorosityPre-Clinical ModelPreclinical ModelsPreclinical TestingProcoagulant ComponentProductionPropertyProtein SecretionProtein TraffickingProteinsProtonsRiskRodentRodentiaRodents MammalsScientific Advances and AccomplishmentsSiliconesSomatic Cell HybridsSourceStrains Cell LinesSubcellular ProcessTechniquesTechnologyTestingTherapeuticThromboplastinogenTimeTransplantationWorkXenograftXenograft procedureXenotransplantationantihemophilic factor Abeta cell therapybetacell therapybio-engineeredbio-engineersbiocompatibilitybioelectronicsbioengineeringbiologicbiological engineeringbiological materialbiomaterial compatibilitybiomedical implantcapsulecell based interventioncell engineeringcell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular engineeringcellular therapeuticcellular therapycellular transplantchronic disorderclinical translationclinically translatablecomplex Blood-coagulation factor VIIIcultured cell linedensitydesigndesigningdevelopmentaldiabetesdisease modeldisorder modeldrug/agenteconomicelectronicelectronic deviceepigenetic gene silencingepigenetic silencingflexibilityflexiblehepatic diseasehepatopathyhost responseimmune functionimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunogenicimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimplant deviceimplantable deviceimplantationimprovedin vivoindwelling deviceisletliver disordermembrane structuremicrocapsulemodel of animalmouse modelmurine modelnative protein drugnon-human primatenonhuman primatenovelopticaloptogeneticsoxygen transportpharmaceutical proteinplatelet cofactor Ipre-clinical testingpreventpreventingprotein drug agentprotein transportprotein-based drugresponsescientific accomplishmentsscientific advancessolid statestable cell linestandard of caresurface coatingtech developmenttechnology developmenttherapeutic proteinthromboplastinogen Atransgene expressiontransplantwirelessxeno-transplantxeno-transplantationβ-cellβ-cell therapyβ-cellsβCell

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Description preview

Cell-based therapies, where naturally or artificially engineered cells secreting therapeutic
proteins are grafted onto the body to act as biological drug factories, are an attractive
approach for long-term treatment of chronic diseases such as hemophilia, diabetes and liver
disorders. However, ‘off the shelf’ therapeutic cells are immunogenic to…

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