grant
Small Molecule Ligands Targeting Pathological Tau Signaling In AD And Related Dementias
Organization UNIVERSITY OF ILLINOIS AT CHICAGOLocation Chicago, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAD pathologyAD related dementiaADRDAcuteAdultAdult HumanAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimers DementiaAmino AcidsAntibody TherapyAssayBindingBioassayBioavailabilityBiochemicalBiological AssayBiological AvailabilityBiophysicsBlood CirculationBloodstreamBrainBrain DiseasesBrain DisordersBrain Nervous SystemCell BodyCell Communication and SignalingCell Culture TechniquesCell DeathCell Membrane PermeabilityCell SignalingCellsCharacteristicsChemicalsClinical Treatment MoabCognitive ManifestationsCognitive SymptomsCorticodentatonigral degeneration with neuronal achromasiaCritical PathsCritical PathwaysDegenerative Neurologic DisordersDevelopmentDiseaseDisorderDockingDoseEncephalonEncephalon DiseasesEventExhibitsFTD dementiaFrontal Temporal DementiaFrontotemporal DementiaGliaGlial CellsGlycogen Synthase KinasesHereditaryHigh Throughput AssayHistologicHistologicallyHumanImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInduced pluripotent stem cell derived neuronsInheritedIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersKinasesKinesinKolliker's reticulumLeadLigand BindingLigandsLobeMT-bound tauMediatingMiceMice MammalsMicro-tubuleMicrotubulesModelingModern ManMolecularMolecular InteractionMolecular WeightMonoclonal AntibodiesMorphologyMotorMurineMusN-terminalNH2-terminalNerve CellsNerve DegenerationNerve Impulse TransmissionNerve TransmissionNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologicNeurologic Degenerative ConditionsNeurologicalNeuron DegenerationNeuron from iPSCNeuron from induced pluripotent stem cellsNeuronal TransmissionNeuronsNon-neuronal cellNonneuronal cellParalysis AgitansParkinsonParkinson DiseasePathogenesisPathologicPathway interactionsPatientsPb elementPharmacological StudyPharmacology StudyPhenotypePhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhosphoric Monoester HydrolasesPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiologic AvailabilityPlayPreventionPrimary ParkinsonismPrimary Senile Degenerative DementiaProgressive Supranuclear OphthalmoplegiaProgressive Supranuclear PalsyPropertyProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein PhosphorylationProtein phosphataseResearchRodentRodentiaRodents MammalsRoleSafetySeriesSignal TransductionSignal Transduction SystemsSignalingSteele-Richardson-Olszewski DiseaseSteele-Richardson-Olszewski SyndromeStructure-Activity RelationshipTauopathiesTestingTherapeuticTherapeutic UsesToxic effectToxicitiesTransgenic MiceTransphosphorylasesTraumatic encephalopathyWestern BlottingWestern ImmunoblottingWild Type Mouseabnormal tauadulthoodaminoacidantibody based therapiesantibody treatmentantibody-based therapeuticsantibody-based treatmentaxon signalingaxon-glial signalingaxonal degenerationaxonal signalingbehavior phenotypebehavior testbehavioral phenotypingbehavioral testbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescell culturecell cultureschemical structure functionchronic traumatic encephalopathycortical basal degenerationcorticobasal degenerationdegenerative axondegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdetermine efficacydevelopmentaldosageeffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexperimentexperimental researchexperimental studyexperimentsfast axonal transportfront temporal dementiafrontal lobe dementiafrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobe degeneration associated with dementiagain of functiongene correctedgene correctiongenomic correctionglia signalingglial signalingheavy metal Pbheavy metal leadhigh throughput screeninghyper-phosphorylated tauhyperphosphorylated tauiPS neuronsiPSC derived-neuronsimmunocytochemistryimmunoreactivityimprovedinduced pluripotent stem cell neuronslead optimizationlife spanlifespanlobesmAbsmembrane permeabilitymicrotubule associated protein tau mutationmicrotubule bound taumicrotubule-associated protein tau mutationmicrotubule-bound taumonoclonal Absmotor symptommouse modelmurine modelmutant taumutation in microtubule associated protein taumutation in microtubule-associated protein taunecrocytosisnerve cell deathnerve cell lossnerve cementnerve signalingneural degenerationneural signalingneurobehavioral symptomneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuronal signalingneurons derived from induced pluripotent stem cellsneurons differentiated from induced pluripotent stem cellsneuropathologic tauneuropathological tauneurotransmissionnovelp-taup-τpathogenic taupathogenic tau gene mutationpathological change in taupathwaypeptide aminoacid sequencepeptide sequencephospho-tauphospho-τphosphorylated taupost-translational modification of tauposttranslational modification of taupre-clinical studypre-clinical trialpreclinical studypreclinical trialpreventpreventingprimary degenerative dementiaprotein activationprotein aminoacid sequenceprotein blottingsenile dementia of the Alzheimer typesmall moleculesocial rolestructure function relationshipsynapse functionsynapse inhibitionsynaptic functionsynaptic inhibitiontautau Proteinstau abnormalitytau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau interactiontau intronic mutationtau mediated neurodegenerationtau mutationtau neurodegenerative diseasetau neuropathologytau pathological changetau pathologytau pathophysiologytau phosphorylationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytauopathic neurodegenerative disordertauopathytherapeutic targetwildtype mouseτ Proteinsτ interactionτ mutationτ phosphorylation
Description preview
Abstract
Tau plays a significant role in pathogenesis of many adult-onset neurodegenerative diseases. Misfolded and
hyperphosphorylated tau is pathognomic for Alzheimer’s disease and Chronic Traumatic Encephalopathy, as
well as playing a secondary role in other diseases such as Parkinson’s disease. In addition, tau mutations
cause diseases such as…
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