grant
Small Molecular Inactivators of HIV
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusAcetyl CoAAcetyl Coenzyme AAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusBiological TestingClinicalCollaborationsDeath RateDiseaseDisorderDrug KineticsDrug PrecursorsDrug resistanceDrugsFDA approvedFemaleFormulationGenerationsHIVHIV InfectionsHIV resistanceHIV resistantHIV-1HIV-IHIV1HTLV-III InfectionsHTLV-III-LAV InfectionsHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman immunodeficiency virus 1InjectableIntermediary MetabolismL-LysineLAV-HTLV-IIILeadLymphadenopathy-Associated VirusLysineMedicationMetabolic ProcessesMetabolismModern ManMolecularPBMCPb elementPeripheral Blood Mononuclear CellPharmaceutical PreparationsPharmacokineticsPositionPositioning AttributePro-DrugsProcessProdrugsProteinsResistance developmentResistant developmentS-acetate Coenzyme AToxic effectToxicitiesTranslatingTransmissionVaccinesVariantVariationViralViral ActivityViral FunctionViral PhysiologyVirusVirus ReplicationVirus-HIVWorkchemical synthesisdeveloping resistancedrug resistantdrug/agentheavy metal Pbheavy metal leadin vivomalemicrobicidalmicrobicidemortality ratemortality ratiopre-clinical toxicitypreclinical toxicitypreventpreventingresistance strainresistance to Drugresistant strainresistant to Drugscaffoldscaffoldingtransacylationtransmission processviral multiplicationviral replicationvirus multiplication♀♂
Description preview
We have developed and studied our molecule both in the active form and as a prodrug. We have developed large-scale syntheses for these molecules and worked in collaboration to study their antiviral activity and evaluate their preclinical toxicity. Overall, the molecules show broad range of activity across a panel of HIV-1 clinical isolates in…
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