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Small GTPases in the biology of platelets and megakaryocytes

Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 21 Mar 2019Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AdhesionsApproaches to preventionAssayBioassayBiochemicalBiologicalBiological AssayBiologyBiosensorBleedingBloodBlood CellsBlood Coagulation DisordersBlood Platelet CountBlood Platelet NumberBlood PlateletsBlood Reticuloendothelial SystemBlood VesselsBlood megakaryocyteBone MarrowBone Marrow Reticuloendothelial SystemCardiac infarctionCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell SignalingCellsClinical ResearchClinical StudyCoagulation DisorderCoagulopathyDeep Vein ThrombosisDeep-Venous ThrombosisDevelopmentDiagnosisDiseaseDisorderFundingFutureGTP PhosphohydrolasesGTPasesGoalsGrantGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHeart VascularHemorrhageHemostasisHemostatic AgentsHemostatic functionHemostaticsHereditaryHumanIn VitroInflammationInheritedIntracellular Communication and SignalingLifeMarrow plateletMegakaryocytesMegalokaryocyteMiceMice MammalsModern ManMolecularMolecular FingerprintingMolecular ProfilingMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMurineMusMyocardial InfarctMyocardial InfarctionNHLBINational Heart, Lung, and Blood InstitutePathologyPathway interactionsPeripheralPeripheral Blood CellPersonalized medical approachPhagocytesPhagocytic CellPhlebothrombosisPlatelet ActivationPlatelet CountPlatelet Count measurementPlatelet NumberPlateletsPrevention approachProcessProductionProliferatingRegulationRiskRoleSignal TransductionSignal Transduction SystemsSignalingSmall G-ProteinsSmall GTPasesThrombocytesThrombocytopeniaThrombopeniaThrombosisVenous ThrombosisWorkamebocytebiologicbiological sensorbiological signal transductionbleeding disorderblood losscardiac infarctcirculatory systemclotting disordercontinuous monitoringcoronary attackcoronary infarctcoronary infarctiondevelopmentalguanosinetriphosphataseheart attackheart infarctheart infarctionimprovedindividualized approachinhibitorinter-individual variabilityinter-individual variationmolecular profilemolecular signaturemouse modelmurine modelnew approachesnovelnovel approachesnovel strategiesnovel strategyoptogeneticspathwaypersonalized approachplatelet functionplatelet homeostasispodoplaninprecision approachpreservationrhoshear stresssocial roletailored approachthromboembolic complicationsthrombosis complicationsthrombotic complicationsthrombotic diseasethrombotic disordertooltransfusion medicinevascular

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ABSTRACT
Mammalian platelets are small anucleate blood cells specialized to continuously monitor and preserve the
integrity of the cardiovascular system (hemostasis). They are produced by megakaryocytes (MKs) in the bone
marrow and released into blood, where they circulate for ten days in humans and five days in mice until they
get cleared by…

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Small GTPases in the biology of platelets and megakaryocytes — UNIV OF NORTH CAROLINA CHAPEL HILL | UNITED STATES | Mar | Dev Procure