grant

Small Focus/Transparent Transducers for Transcranial Ultrasound Stimulation in Mice

Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AD dementiaAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmmon HornAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnimalsBiologic ModelsBiologicalBiological ModelsBiophysical ProcessBiophysicsBlood - brain barrier anatomyBlood flowBlood-Brain BarrierBrainBrain Nervous SystemBrain regionCNS DiseasesCNS disorderCell BodyCellsCentral Nervous System DiseasesCentral Nervous System DisordersCephalicChemicalsClinical Medical SciencesClinical MedicineComplementComplement ProteinsContralateralCornu AmmonisCountryCranialDataDependenceEchographyEchotomographyEncephalonFaceFamilyFluorescenceFrequenciesFunctional MRIFunctional Magnetic Resonance ImagingGoalsHeadHemato-Encephalic BarrierHippocampusHumanImageImaging DeviceImaging InstrumentImaging ToolIn VitroInvestigatorsIon ChannelIonic ChannelsKnowledgeLocationMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMechanical StimulationMechanicsMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedical UltrasoundMembrane ChannelsMental DepressionMiceMice MammalsModel SystemModelingModern ManMolecularMurineMusNMR ImagingNMR TomographyNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuronsNeurosciencesNuclear Magnetic Resonance ImagingOpticsPETPET ScanPET imagingPETSCANPETTPerformancePhysiologicPhysiologicalPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaRad.-PETResearchResearch PersonnelResearchersResolutionResortRiskScienceSensorySkullSliceSpecificitySpottingsSubstance Use DisorderSystemTechniquesTechnologyTemperatureTransducersUltrasonic ImagingUltrasonic TransducerUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestUltrasound transducerVisual CortexWorkZeugmatographyawakebehavior studybehavioral studybiologicbiophysical analysisbiophysical foundationbiophysical mechanismbiophysical principlesbiophysical sciencesbiophysical studiesbloodbrain barriercalcium indicatorclinical applicabilityclinical applicationcognitive functioncold temperaturecomplementationcraniumdepressiondiagnostic ultrasoundemotional functioningexperiencefMRIfacesfacialhippocampalimagingimaging in miceimaging studies for miceimaging studies in micein vivoinnovateinnovationinnovativelow temperaturemechanicmechanicalmice imagingmodel of animalmurine imagingneuralneural circuitneural circuitryneural controlneural imagingneural regulationneuro-imagingneurocircuitryneuroimagingneurological diseaseneurological imagingneuromodulationneuromodulatoryneuronalneurophysiologicalneurophysiologyneuroregulationnon-human primatenonhuman primatenoveloptic imagingopticaloptical imagingpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinical studypreclinical studyprimary degenerative dementiaresolutionsresponsesenile dementia of the Alzheimer typesonogramsonographysound measurementsubstance use and disordersynaptic circuitsynaptic circuitrytooltranslation to humansultrasoundultrasound imagingultrasound scanningvisual cortical
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Project Summary
Human neuroscience does not currently have a noninvasive tool to focally modulate activity anywhere in the brain.

This is a critical unmet need: without a focal brain-wide neuromodulation technique, hypotheses on neural circuit

function generated from neuroimaging and behavioral studies remain correlational, and circuit-based…

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