grant
Slowing Atherothrombosis Progression through Indoor Air Filtration: A Crossover Trial in Hispanic and non-Hispanic Adults with Ischemic Heart Disease History
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Sept 2022Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202421+ years oldAcuteAdultAdult HumanAdverse effectsAgeAirAir PollutionApoplexyAreaAtherosclerosisAtherosclerotic Cardiovascular DiseaseB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Biological MarkersBlood ClottingBlood GlucoseBlood PlasmaBlood PressureBlood SugarBlood coagulationBrain Vascular AccidentC-reactive proteinCD62P AntigensCalendarCalibrationCaliforniaCardiac infarctionCardiometabolic DiseaseCardiometabolic DisorderCardiovascular DiseasesCause of DeathCensusesCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChinaClinicalComputerized Medical RecordCross-Over DesignsCross-Over StudiesCross-Over TrialsCrossover DesignCrossover StudiesCrossover TrialsDataDevicesDiabetes MellitusDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyElectronic Medical RecordEnrollmentEnvironmental FactorEnvironmental Risk FactorEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEthnic OriginEthnicityEventExposure toFemaleFiltrationFiltration FractionationFutureGMP-140GoalsGroups at riskHEPA FilterHEPA FiltrationHEPA cleanerHPGFHealthHeart failureHepatocyte-Stimulating FactorHispanicHispanic PopulationsHispanic groupHispanic individualHispanic peopleHispanicsHistoryHome visitationHouse CallHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinIn VitroIncidenceIndividuals from minorityIndividuals of minorityInflammatoryInterleukin-6InternationalInterventionIntervention StrategiesIntervention TrialInterventional trialInvestigatorsIschemic HeartIschemic Heart DiseaseIschemic myocardiumLECAM-3LifeLife StyleLifestyleLinkLos AngelesMGI-2Mainland ChinaMeasuresMethodsMinority GroupsMinority PeopleMinority PopulationMinority individualMonitorMorbidityMorbidity - disease rateMulti-center trialMulticenter TrialsMyeloid Differentiation-Inducing ProteinMyocardial InfarctMyocardial InfarctionMyocardial IschemiaNational Institutes of HealthNon-HispanicNonhispanicNot Hispanic or LatinoOlder PopulationOutcomeP-SelectinPM2.5ParticipantParticulatePatientsPeople at riskPersonsPersons at riskPhysiologic pulsePlasmaPlasma SerumPlasmacytoma Growth FactorPlatelet alpha-Granule Membrane ProteinPollutionPopulation HeterogeneityPopulations at RiskPredispositionProcessProteins, specific or class, C-reactiveProteomicsPulseQuestionnairesRandomizedRecording of previous eventsResearch DesignResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRistocetin CofactorRistocetin-Willebrand FactorSamplingSpecific qualifier valueSpecifiedStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStrokeStudy TypeSubgroupSudden DeathSusceptibilityTeenTeenagersThrombosisTimeUnited StatesUnited States National Institutes of HealthUniversitiesUniversity resourcesVariantVariationVulnerable PopulationsWildfireWomanaccelerated agingaccelerated biological ageaccelerated biological agingadulthoodage accelerationagesair cleanerair filtrationair monitoringarterial stiffeningarterial stiffnessartery stiffeningartery stiffnessatheromatosisatherosclerotic diseaseatherosclerotic vascular diseaseatherothrombosisbio-markersbiologic markerbiomarkerbrain attackburden of diseaseburden of illnesscardiac failurecardiac infarctcardiac ischemiacardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular riskcardiovascular risk factorcerebral vascular accidentcerebrovascular accidentcoronary attackcoronary infarctcoronary infarctioncoronary ischemiacostdesigndesigningdetermine efficacydiabetesdisease burdendiverse populationsefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy testingenrollenvironmental riskepidemiologic investigationepidemiology studyethnic diversityethnically diverseevaluate efficacyexamine efficacyexperiencefeasibility trialfine particlesfine particulate matterheart attackheart infarctheart infarctionheart ischemiaheterogeneous populationhigh efficiency particulate air cleanerhigh efficiency particulate air filterhigh-efficiency particulate air purifierhistorieshome visitimprovedin vivoindexingindoor PMindoor airindoor air particulate matterindoor fine particlesindoor particulate matterinterestinterferon beta 2intervention arminterventional strategymalemenmeteorological datamortalitymyocardial ischemia/hypoxiamyocardium ischemianon-smokernonsmokernovelolder adultolder adulthoodolder groupsolder individualsolder personpollutantpopulation diversityportabilitypreventpreventingprimary outcomerandomisationrandomizationrandomly assignedresidenceresidential buildingresidential siteresponsesecondary outcomesexstatistical analysisstrokedstrokesstudy designsystemic inflammationsystemic inflammatory responseteen yearsteenagethrombotic diseasethrombotic disordertreatment armtrial comparingvon Willebrand Factorvon Willebrand Proteinvulnerable groupvulnerable individualvulnerable peopleweather datawild firewildland fire
Description preview
ABSTRACT
Cardiovascular disease (CVD) is the leading cause of death in the US. There has been an increasing
recognition of the important contribution of fine particulate pollution (PM2.5) to CVD morbidity and mortality.
Mounting evidence suggests that the use of indoor air filtration to reduce PM2.5 exposure from days to weeks
leads to…
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