grant
Sleep and Temperature Disturbance as risk factors for Alzheimer's Disease in Down Syndrome: a Longitudinal Study
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202621+ years oldA β-42A β42A-beta 42A-beta42AD biological markerAD biomarkerAD dementiaAD pathologyAD related biomarkerAD riskAD risk factorAPOE e4APOE-ε4APOEε4Abeta-42Abeta42AccelerationActive Follow-upAdultAdult HumanAffectAgeAge of OnsetAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimer's disease biomarkerAlzheimer's disease pathologyAlzheimer's disease related biomarkerAlzheimer's disease riskAlzheimer's pathologyAlzheimer's related biomarkerAlzheimers DementiaAlzheimer’s biological markerAmmon HornAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-42Amyloid beta-ProteinAmyloid beta42Amyloid βAmyloid β-42Amyloid β-PeptideAmyloid β-ProteinAmyloid β42Amyloidβ-42Amyloidβ42ApneaAβAβ-42Aβ42Biological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBody TemperatureBody Temperature RegulationBody ThermoregulationBrainBrain Nervous SystemBrain regionCause of DeathCerebrospinal FluidCircadian DysregulationCircadian RhythmsClinicalCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollectionCornu AmmonisDataData CollectionDelta WaveDelta Wave sleepDisease MarkerDisease ProgressionDisturbance in cognitionDown SyndromeDysfunctionEOADEarly Onset Alzheimer DiseaseEncephalonEvaluationFunctional disorderGeneticGenetic DiseasesGoalsHeterogeneityHigh PrevalenceHippocampusHomeHourImpaired cognitionIndividualIndividuals with down syndromeIntellectual disabilityIntellectual functioning disabilityIntellectual limitationInterventionLangdon Down syndromeLeadLife ExpectancyLightLiteratureLongitudinal StudiesLongitudinal SurveysLongitudinal observational studyMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingMeasurementMeasuresMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceModelingMongolismNMR ImagingNMR TomographyNerve DegenerationNeuron DegenerationNuclear Magnetic Resonance ImagingNyctohemeral RhythmObstructive Sleep ApneaOnset of illnessOutcomePETPET ScanPET imagingPETSCANPETTPathologyPb elementPersonsPhotoradiationPhysiologic ThermoregulationPhysiopathologyPlasmaPlasma SerumPolysomnographyPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaRad.-PETResearchReticuloendothelial System, Serum, PlasmaRisk FactorsSeveritiesSleepSleep MonitoringSleep disturbancesSlow-Wave SleepSomnographyStructureStudy modelsSyndrome, Sleep Apnea, ObstructiveTauopathiesTelemetriesTelemetryTemperatureTestingThermoregulationThickThicknessTrisomy 21Twenty-Four Hour RhythmWorkWristZeugmatographya beta peptideaberrant sleepabetaactigraphactigraphyactive followupadulthoodage associatedage correlatedage dependentage linkedage relatedage specificagedagesalzheimer riskamyloid betaamyloid-b proteinapo E-4apo E4apo epsilon4apoE epsilon 4apoE-4apoE4apolipoprotein E epsilon 4apolipoprotein E-4apolipoprotein E4autosomal dominant ADautosomal dominant Alzheimer's diseasebeta amyloid fibrilbio-markersbiologic markerbiomarkerbiomarker in ADbiomarker in Alzheimer'sbiomarker in Alzheimer's diseasecerebral spinal fluidchromosome 21 trisomychromosome 21 trisomy syndromecircadiancircadian abnormalitycircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian processcircadian rhythmicitycognitive assessmentcognitive changecognitive dysfunctioncognitive losscognitive performancecognitive testingcohortcongenital acromicria syndromecumulative riskdaily biorhythmdisease onsetdisorder onsetdisrupted sleepdisturbed sleepdown syndrome individualsdown syndrome patientsearly onset ADearly onset Alzheimer'sfollow upfollow-upfollowed upfollowupgenetic conditiongenetic disorderheavy metal Pbheavy metal leadhigh riskhippocampalhomesimpaired sleepindexingintellectual and developmental disabilityirregular sleeplater in lifelater lifelife-time risklifetime risklimited intellectual functioninglong term observational studylong-term studylongitudinal outcome studieslongitudinal research studymalleable riskmicrotubule bound taumicrotubule-bound taumodifiable riskmorbus Downneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurofilamentneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropathologic tauneuropathological taunovelolder adultolder adulthoodp-taup-τpathophysiologypatients with down syndromepeople with down syndromephospho-tauphospho-τphosphorylated taupositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of tauposttranslational modification of taupre-clinicalpreclinicalprimary degenerative dementiaprogression biomarkerprogression markerpseudohypertrophic progressive muscular dystrophyrate of changerecruitrisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk of developing Alzheimer'sscreeningscreeningssenile dementia of the Alzheimer typesexsleep amountsleep disruptionsleep durationsleep dysregulationsleep episodesleep intervalsleep lengthsleep measurementsleep periodsleep polysomnographysleep quantitysleep timesleep/wake disruptionsleep/wake disturbancesoluble amyloid precursor proteinspinal fluidsymptomatologytautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau phosphorylationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytauopathic neurodegenerative disordertauopathytelemetrictime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtrisomy 21 syndromeuptakeτ Proteinsτ phosphorylation
Description preview
Project Summary Abstract
Down syndrome (DS), the most frequent form of intellectual disability of genetic origin, involves a >95%
cumulative risk of Alzheimer’s Disease (AD) by the seventh decade. Further, AD is now the most common cause
of death in this population as life expectancy in DS individuals has increased. Importantly, while AD in DS…
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