grant
Skeletal Stem Cell-based Cartilage Regeneration in Aged and Osteoarthritic Niches
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 15 May 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20262 year old2 years of age21+ years oldAdultAdult HumanAffectAgeAgingAmericanArthroplastyAssayBMP-2BMP-2ABMP2BMP2 geneBMP2A GeneBar CodesBasic ResearchBasic ScienceBioassayBiologicalBiological AssayBiomechanicsBiomedical EngineeringBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBone Morphogenetic Protein 2 GeneBone Morphogenetic Protein 2A GeneBone remodelingBrainBrain Nervous SystemCartilageCartilaginous TissueCell BodyCell Communication and SignalingCell LineageCell SignalingCellsChemicalsChondrocytesChondrogenesisCicatrixClinicalClone CellsCommunicationCompetenceDataDefectDegenerative ArthritisDegenerative DisorderDegenerative polyarthritisDeteriorationDevelopmentDiseaseDisorderEncephalonEndocrine Gland SecretionEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsFGF-7Fibroblast Growth Factor 7FibroblastsFibrocartilagesFibrosisGene ExpressionGene TranscriptionGenetic TranscriptionGrowth AgentsGrowth FactorGrowth SubstancesHealthHistologicHistologicallyHormonesHumanHyaline CartilageImpairmentIn SituIn VitroIndividualInferiorInflammatoryIntracellular Communication and SignalingInvestigationJoint Prosthesis ImplantationJointsKnowledgeMapsMedial MenisciMedial meniscus structureMediatingMeniscus MedialisMethodsMiceMice MammalsModelingModern ManMolecularMonitorMurineMusMusculoskeletalNatural regenerationOperative ProceduresOperative Surgical ProceduresOsteoarthritisOsteoarthrosisOutputPainPain ControlPain TherapyPain managementPainfulPre-Clinical ModelPreclinical ModelsProgenitor CellsPropertyProteins Growth FactorsPublishingRNA ExpressionRegenerationReplacement ArthroplastyResearchResting progenitorSDGF-3ScarsSignal TransductionSignal Transduction SystemsSignalingSkeletonSocietiesStimulusSurgicalSurgical InterventionsSurgical ProcedureTechnologyTestingTherapeuticTherapeutic AgentsThickThicknessTissue EngineeringTissuesTranscriptionTranslatingTransplantationVegf InhibitorWorkadulthoodage 2age 2 yearsage associatedage associated diseaseage associated disorderage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentagedaged 2 yearsaged miceaged mouseaged two yearsagesarticular cartilagebarcodebio-engineeredbio-engineersbioengineered tissuebioengineeringbiologicbiological engineeringbiological signal transductionbiomechanicalbone morphogenetic protein 2cartilage regenerationcartilage repaircostdegenerative conditiondegenerative diseasedegenerative joint diseasedevelopmentaldormant stem celleffective therapyeffective treatmentelderly miceendogenous progenitorendogenous stem cellsengineered tissueenhancing factorepigeneticallyexperimentexperimental researchexperimental studyexperimentsfibrocartilaginousfibrogenesishigh definitionhigh-resolutionhypertrophic arthritisimprovedin vivoinactive stem cellinnovative technologiesinsightjoint arthroplastyjoint degenerationjoint degradationjoint destructionjoint replacementjoint tissue degenerationjuvenile animalkeratinocyte growth factorlatent progenitorlatent stem cellnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyold micepain interventionpain treatmentpaliferminpharmacologicphysical disabilityphysically disabledphysically handicappedpostnatalpre-clinical studypreclinical studypreventpreventingprogenitor biologyprogenitor cell based therapyprogenitor cell biologyprogenitor cell differentiationprogenitor cell fateprogenitor cell nicheprogenitor cell therapyprogenitor cell treatmentprogenitor differentiationprogenitor fateprogenitor nicheprogenitor therapyprogenitor treatmentprogramsquiescent progenitorquiescent stem cellsregenerateregenerativerepairrepairedresting stem cellscRNA sequencingscRNA-seqsexsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskeletalskeletal progenitorskeletal progenitor cellskeletal regenerationskeletal stem cellskeletonsspatial relationshipstem and progenitor biologystem and progenitor cell fatestem and progenitor cell nichestem and progenitor cell therapystem and progenitor differentiationstem cell based therapystem cell biologystem cell differentiationstem cell fatestem cell mediated therapystem cell nichestem cell quiescencestem cell therapeuticsstem cell therapystem cell treatmentstem cell-based therapeuticstem cell-based treatmentstem cellssubchondral bonesurgerytranscriptomicstranslational studytransplanttwo year oldtwo years of ageyoung animal
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Project Summary
Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of hyaline
cartilage lining articular joints. A critical challenge for OA management is the development of an effective
treatment that reverses cartilage damage. Our previous work indicates the existence of adult skeletal stem
cells…
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