grant
Sinus Disease in Young Children with Cystic Fibrosis
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 15 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAccessory SinusesAdultAdult HumanAgeAirway infectionsAlimentary CanalAnosmiaAntibiotic AgentsAntibiotic DrugsAntibioticsBiologicalBirthBody SystemCF PreschoolersCF patientsCFTRCFTR ProteinChildChild YouthChildren (0-21)Children with CFChronicClinicalCollaborationsCollectionComplicationControl GroupsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDNA TherapyDataDevelopmentDigestive TractDiseaseDisorderEarly treatmentEligibilityEligibility DeterminationEndocrineEnrollmentEnsureEvaluationFoundationsFundingFutureGI TractGastrointestinal TractGastrointestinal tract structureGene Transfer ClinicalGeneralized GrowthGenetic InterventionGoalsGrowthHealthHealth StatusImpairmentInferiorInflammationInvestigationIonizing Electromagnetic RadiationIonizing radiationIvacaftorLevel of HealthLifeLong-Term EffectsLongitudinal StudiesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMatched GroupMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental DepressionMiscellaneous AntibioticModelingMorbidityMorbidity - disease rateMucoviscidosisMulti-center studiesMulticenter StudiesNMR ImagingNMR TomographyNasal SinusesNasal cavityNasal cavity/ParanasalNasal cavity/Paranasal sinusesNerve CellsNerve UnitNeural CellNeurocyteNeuronsNuclear Magnetic Resonance ImagingNutritionNutritionalNutritional statusObservation researchObservation studyObservational StudyObservational researchOdorsOlfactionOlfactory dysfunctionOrganOrgan SystemOutcomeOutcome MeasureOutcome StudyParanasal SinusesParturitionPathway interactionsPersonsPhaseProcessProspective StudiesProteinsProtocol ScreeningQOLQOL improvementQuality of lifeRadiation exposureRadiation-Ionizing TotalRefractoryResearchResearch PriorityResolutionRespiratory InfectionsRespiratory Tract InfectionsSeveritiesSinusSinusitisSiteSkullSmellSmell PerceptionSymptom BurdenTechniquesTestingTimeTissue GrowthVX-770WorkYouthYouth 10-21Zeugmatographyadulthoodage groupagedagesairway epithelium inflammationairway inflammationalimentary tractanosphrasiabiologicchildren with cystic fibrosischronic rhinosinusitisco-morbidco-morbiditycommunity researchcomorbiditycraniumcystic fibrosis patientscystic fibrosis preschoolerscystic fibrosis transmembrane regulatordata sharingdepressiondevelopmentaldigestive canaldisease natural historyearly therapyeffective therapyeffective treatmentenrollexperiencegastrointestinalgene repair therapygene therapygene-based therapygenetic therapygenomic therapyhealth levelimprovedimprovements in QOLimprovements in quality of lifeindividuals with CFindividuals with cystic fibrosisinstrumentionizing outputkidslater in lifelater lifelong-term studylongitudinal outcome studiesloss of smelllung healthmeasurable outcomeneuroepitheliumneuronalnutritiousodor perceptionolfactory bulbolfactory impairmentolfactory lossolfactory perceptionontogenyoutcome measurementpathwaypatients with CFpatients with cystic fibrosispediatric cystic fibrosispreventpreventingprospectivepulmonarypulmonary healthquality of life improvementresolutionsrespiratory inflammationrespiratory tract inflammationscreeningscreeningstheoriestreatment groupyounger ageyoungsteryouth age
Description preview
PROJECT SUMMARY/ABSTRACT
Cystic fibrosis (CF) is a chronic, multi-organ process characterized by inspissated secretions that adversely
impact the upper and lower airway, gastrointestinal tract, and other organ systems. Chronic rhinosinusitis (CRS)
is a prevalent and clinically impactful disease complication in individuals with CF. CRS is…
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