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Single cell transcriptomics of HIV persistence and latency
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 19 Mar 2021Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteAlimentary CanalAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesBar CodesBehaviorBindingBiologic ModelsBiologicalBiological ModelsBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCITE sequencingCITE-seqCITEseqCell BodyCell CommunicationCell CountCell InteractionCell LineageCell NumberCell SurvivalCell ViabilityCell-to-Cell InteractionCellsCellular Indexing of Transcriptomes and Epitopes by SequencingCirculatory CollapseClassificationDevelopmentDifferential Gene ExpressionDigestive TractDisease ProgressionDrugsExpression SignatureGI TractGastrointestinal TractGastrointestinal tract structureGene Expression ProfileGene TranscriptionGenesGenetic TranscriptionGenomicsHIVHIV InfectionsHIV-1HIV-IHIV1HTLV-III InfectionsHTLV-III-LAV InfectionsHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman immunodeficiency virus 1ImageImmune systemIn VitroInfectionInterruptionInterventionKnowledgeLAV-HTLV-IIILineage TracingLymphadenopathy-Associated VirusMapsMeasuresMedicationMemoryMethodsMiceMice MammalsModel SystemModelingModern ManMolecular InteractionMorphologyMucosaMucosal TissueMucous MembraneMurineMusNetwork AnalysisPathway AnalysisPathway interactionsPatternPharmaceutical PreparationsPhenotypeProliferatingRNA ExpressionRelapseResearchResolutionShockSpleenSpleen Reticuloendothelial SystemStimulusSuperantigensSystemSystematicsSystems BiologyT-Cell ActivationT-Cell Receptor InteractionT-CellsT-LymphocyteT4 CellsT4 LymphocytesTCR ActivationTCR InteractionTestingTimeTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTissuesTranscriptionViralViral reservoirVirusVirus ReplicationVirus reservoirVirus-HIVactivate T cellsacute infectionalimentary tractantiretroviral therapyantiretroviral treatmentbarcodebiologiccell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular indexing of transcriptomes and epitopes by single cell sequencingcellular lineage mappingcellular lineage trackingcirculatory shockdevelopmentaldigestive canaldrug/agentgene expression patterngene expression signaturegenome profilinggenomic profilinghumanized micehumanized mousehypoimmunityimagingimmune deficiencyimmunodeficiencyimprovedin vivomigrationmodel of animalmouse modelmultiomicsmultiple omicsmurine modelnovelpanomicspathwaypreservationpreventpreventingprogramspurgepurgespurgingresolutionsresponsescRNA sequencingscRNA-seqshockssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell genomicssingle cell transcriptomic profilingsingle-cell RNA sequencingspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsthymus derived lymphocytetranscriptional profiletranscriptional signaturetranscriptomicsviral multiplicationviral replicationvirus multiplication
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Summary
Antiretroviral therapy (ART) in HIV-1 infection suppresses viral replication, preserves and improves the
CD4+ T cell count and prevents disease progression. However, treatment with ART is not curative, and
interruption of therapy consistently unleashes viral relapse. The persistence of a viral reservoir following ART
is the major obstacle…
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